PDF DatasheetRat Podocalyxin Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Podocalyxin based upon sequence from Rat
Host: QP9939 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Rattus norvegicus (Rat) Podocalyxin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP9939.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Gln25 – Ser386
Amino Acid Sequence: QDNGNKTDTS DITSIDQNQD KPATNQPSNA TPKSSVQPPT PTSISTSSPD PKATQSSNSS VTTTSDSTTD RTSSSTSTVP TTSNSGQTVS SGGKSSDKIT TALPTTLGPV NASSQPTDLN TSTKLPSTPT TNSTASPHQP VSHSEGQHTT VQSSSASVSS SDNTTLLWIL TTSKPTGTSE GTQPIAISTP GITTPVSTPL QPTGSPGGTE SVPTTEEFTH STSSWTPVVS QGPSTPSSTW TSGSYKLKCD PAIKPHEELL ILNLTRDSFC KGSPPNERFL ELLCHSAKAS FKPAEDSCAL ELAPILDNMS -QAVAVKRIV IETKLSPKAV FELLKDKWDD LTEAGVIDIH LGKEGPPEVN EDRFS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Rat Podocalyxin Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Rat Podocalyxin Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PODXL |
| Entrez Gene ID | 192181 |
| Ensemble Gene ID | ENSRNOG00000012495 |
| RefSeq Protein Accession(s) | NP_620203.1 |
| RefSeq mRNA Accession(s) | NM_138848.1, XM_008762758.2, XM_017592427.1 |
| UniProt ID(s) | Q9WTQ2 |
| UniGene ID(s) | Rn.162741 |
| COSMIC ID Link(s) | PODXL |
| KEGG Gene ID(s) | rno:192181 |
| General Description of Recombinant Rat Podocalyxin Protein. | |
| Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma mbrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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