PDF DatasheetHuman FOXP3 / Scurfin Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant FOXP3 / Scurfin based upon sequence from: Human
Host: QP8828 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) FOXP3 / Scurfin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8828.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Leu260
Amino Acid Sequence: MPNPRPGKPS APSLALGPSP GASPSWRAAP KASDLLGARG PGGTFQGRDL RGGAHASSSS LNPMPPSQLQ LPTLPLVMVA PSGARLGPLP HLQALLQDRP HFMHQLSTVD AHARTPVLQV HPLESPAMIS LTPPTTATGV FSLKARPGLP PGINVASLEW VSREPALLCT FPNPSAPRKD STLSAVPQSS YPLLANGVCK WPGCEKVFEE PEDFLKHCQA DHLLDEKGRA QCLLQREMVQ SLEQQLVLEK EKLSAMQAHL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human FOXP3 / Scurfin Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human FOXP3 / Scurfin Protein General Information | |
|---|---|
| Alternate Names | |
| FOXP3; Scurfin; AIID; DIETER; XPID; JM2; IPEX; PIDX | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | FOXP3 |
| Entrez Gene ID | 50943 |
| Ensemble Gene ID | ENSG00000049768 |
| RefSeq Protein Accession(s) | NP_001107849.1 |
| RefSeq mRNA Accession(s) | NM_001114377.1, NM_014009.3 |
| UniProt ID(s) | Q9BZS1 |
| UniGene ID(s) | Hs.247700 |
| HGNC ID(s) | HGNC:6106 |
| COSMIC ID Link(s) | FOXP3 |
| KEGG Gene ID(s) | hsa:50943 |
| PharmGKB ID(s) | PA201094 |
| General Description of Recombinant Human FOXP3 / Scurfin Protein. | |
| Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune syst by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 . Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 . Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 . Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development . Inhibits the transcriptional activator activity of RORA . Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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