PDF DatasheetRat TIMP-1 / TIMP1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant TIMP-1 / TIMP1 based upon sequence from: Rat
Host: QP8876 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Rattus norvegicus (Rat) TIMP-1 / TIMP1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8876.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Cys24 – Ala217
Amino Acid Sequence: CSCAPTHPQT AFCNSDLVIR AKFMGSPEII ETTLYQRYEI KMTKMLKGFD AVGNATGFRF AYTPAMESLC GYVHKSQNRS EEFLIAGRLR NGNLHITACS FLVPWHNLSP AQQKAFVKTY SAGCGVCTVF PCSAIPCKLE SDSHCLWTDQ ILMGSEKGYQ SDHFACLPRN PDLCTWQYLG VSMTRSLPLA KAEA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Rat TIMP-1 / TIMP1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Rat TIMP-1 / TIMP1 Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Timp1 |
| Entrez Gene ID | 116510 |
| Ensemble Gene ID | ENSRNOG00000010208 |
| RefSeq Protein Accession(s) | NP_446271.1 |
| RefSeq mRNA Accession(s) | NM_053819.1, XM_006256608.2 |
| UniProt ID(s) | P30120 |
| UniGene ID(s) | Rn.25754 |
| COSMIC ID Link(s) | Timp1 |
| KEGG Gene ID(s) | rno:116510 |
| General Description of Recombinant Rat TIMP-1 / TIMP1 Protein. | |
| Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates th by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.