PDF DatasheetRat IL17 / IL17a Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL17 / IL17a based upon sequence from Rat
Host: QP5511 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5511.
Bioactivity Data: Rat IL17 / IL17a induces IL-6 production in 3T3 cells measured via ELISA (typical ED50 is ? 1 ng/ml).
Monomer or Dimer: Dimer
Amino Acid Sequence: MAVLIPQSSV CPNAEANNFL QNVKVNLKVL NSLSSKASSR RPSDYLNRST SPWTLSRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPEKCPF TFRVEKMLVG VGCTCVSSIV RHAS
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions: A Certificate of Analysis (CofA) will be sent along with the protein and will contain the proper reconstitution instructions.
Concentration of Rat IL17 / IL17a Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: 10 mM sodium citrate, pH 3.0
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Rat IL17 / IL17a Protein General Information | |
|---|---|
| Alternate Names | |
| IL17, IL17A, CTLA-8, IL-17A, CTLA8, IL-17, IL17 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL17A |
| UniProt ID(s) | Q61453 |
| UniGene ID(s) | Rn.218513 |
| COSMIC ID Link(s) | IL17A |
| General Description of Recombinant Rat IL17 / IL17a Protein . | |
| Interleukin 17A (IL-17A), also known as CTLA-8, is a member of the IL-17 family of proteins. IL-17A is proinflammatory cytokine that is secreted by activated CD4+ and CD8+ T lymphocytes. IL-17A acts through its receptor, IL-17R, to promote increased cytokine and chemokine secretion. In turn, the cytokines and chemokines mediate the immunoregulatory function of IL-17A by promoting the proliferation, maturation, and chemoattraction of neutrophils to inflammatory sites. Elevated levels of IL-17A are associated with rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer, and multiple sclerosis. Human, mouse, and rat IL-17A show activity on mouse cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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