Formalin-fixed, paraffin-embedded human Tonsil stained with CD16 Monoclonal Antibody (1.4C3).
Formalin-fixed, paraffin-embedded human Tonsil stained with CD16 Monoclonal Antibody (1.4C3).

Anti-CD106 / VCAM1 Antibody Clone 1.4C3

$ 488.00
Please Select Product Options Below To View The Catalog Number.

SKU: 7412-MSM1
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
7412-MSM1-P1 Size: 100 ug, Tag: Unconjugated
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SKU: 7412-MSM1-P1
CD106 / VCAM1 General Information
Alternate Names
Vascular cell adhesion protein 1, vascular cell adhesion molecule 1, VCAM-1, cluster of differentiation 106, CD106, VCAM1
Molecular Weight
110kDa
Chromosomal Location
1q21.2
Curated Database and Bioinformatic Data
Gene SymbolVCAM1
Entrez Gene ID7412
Ensemble Gene IDENSG00000162692
RefSeq Protein Accession(s)NP_542413, NP_001186763, NP_001069
RefSeq mRNA Accession(s)NM_001199834, NM_001078, NM_080682
RefSeq Genomic Accession(s)NC_000001, NC_018912, NG_023034
UniProt ID(s)P19320
UniGene ID(s)P19320
HGNC ID(s)12663
Cosmic ID(s)VCAM1
KEGG Gene ID(s)hsa:7412
PharmGKB ID(s)PA37286
General Description of CD106 / VCAM1.
Recognizes a protein of 110kDa, identified as CD106 (also known as vascular cell adhesion molecule-1 (VCAM-1), INCAM-100). CD106 is a member of the Ig superfamily of adhesion molecules, is expressed at high levels on cytokine stimulated vascular endothelial cells,, at minimal levels on un-stimulated endothelial cells. It is also present on follicular, inter-follicular dendritic cells of lymph nodes, myoblasts,, some macrophages. CD106 serves as a ligand for leukocyte integrin (VLA-4 or CD49d/CD29), mediates cell adhesion of leukocytes to activated endothelium. It plays a role in various immunological, inflammatory responses.

Human Anti-CD106 / VCAM1 Antibody Product Attributes

Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-CD106 / VCAM1 Antibody Clone: 1.4C3
Clone 1.4C3 Host and Isotype: Mouse IgG1 kappa
Anti-Human CD106 / VCAM1 Positive Control Sample: Human placenta or tonsil
Cellular Localization of Antibody Cell surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Stimulated human umbilical vein endothelial cells (HUVEC)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

CD106 / VCAM1 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-VCAM1 antibody staining is expected to be primarily localized to the cell junctions.

Observed Antibody Staining Data By Tissue Type:

Variations in CD106 / VCAM1 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of CD106 / VCAM1 could be seen inlymphoid tissue in appendix and germinal center cells in the lymph node. We were unable to detect CD106 / VCAM1 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's CD106 / VCAM1 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-CD106 / VCAM1 Antibody Clone 1.4C3

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