Formalin-fixed, paraffin-embedded human Tonsil stained with CD4 Monoclonal Antibody (C4/165)
Formalin-fixed, paraffin-embedded human Tonsil stained with CD4 Monoclonal Antibody (C4/165)

Anti-CD40 / TNFRSF5 Antibody Clone C40/1605

$ 199.00$ 459.00
Please Select Product Options Below To View The Catalog Number.

SKU: 958-MSM1
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
958-MSM1-P0 Size: 20 ug, Tag: Unconjugated $ 199.00
958-MSM1-P1 Size: 100 ug, Tag: Unconjugated $ 429.00
958-MSM1-P2 Size: 200 ug, Tag: Unconjugated $ 459.00
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In Stock.
Flat Rate Shipping Anywhere in the US: $45
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SKU: 958-MSM1-P0
CD40 / TNFRSF5 General Information
Alternate Names
Cluster of differentiation 40, CD40
Molecular Weight
43kDa
Chromosomal Location
20q12-q13.2
Curated Database and Bioinformatic Data
Gene SymbolCD40
Entrez Gene ID958
Ensemble Gene IDENSG00000101017
RefSeq Protein Accession(s)XP_005260676, XP_016883625, NP_001309350, NP_001309351, XP_016883626, NP_001289682, XP_011527411, NP_001241, NP_690593, XP_016883624
RefSeq mRNA Accession(s)NM_152854, XM_017028137, NR_136327, XM_011529109, NM_001322422, NM_001250, NM_001302753, NM_001322421, NR_126502, XM_005260619, XM_017028135, XM_017028136,
RefSeq Genomic Accession(s)NC_000020, NC_018931, NG_007279
UniProt ID(s)Q6P2H9, A0A0S2Z349, P25942, A0A0S2Z3C7
UniGene ID(s)Q6P2H9, A0A0S2Z349, P25942, A0A0S2Z3C7
HGNC ID(s)11919
Cosmic ID(s)CD40
KEGG Gene ID(s)hsa:958
PharmGKB ID(s)PA36612
General Description of CD40 / TNFRSF5.
CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes, follicular dendritic cells, bone marrow-derived dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zones of secondary lymphoid organs.

Human Anti-CD40 / TNFRSF5 Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-CD40 / TNFRSF5 Antibody Clone: C40/1605
Clone C40/1605 Host and Isotype: Mouse IgG1 kappa
Anti-Human CD40 / TNFRSF5 Positive Control Sample: L-428 Cells. Tonsil, Spleen or Thymus
Cellular Localization of Antibody Cell Surface and Secreted
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length CD40 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

CD40 / TNFRSF5 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in CD40 / TNFRSF5 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the white pulp in spleen and germinal center cells in the lymph node and tonsil. More moderate antibody staining intensity was present in cells in the white pulp in spleen and germinal center cells in the lymph node and tonsil. Low, but measureable presence of CD40 / TNFRSF5 could be seen inlymphoid tissue in appendix and macrophages in lung. We were unable to detect CD40 / TNFRSF5 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of CD40 / TNFRSF5 expression as measured by anti-CD40 / TNFRSF5 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - - - - - - - - + - - - - - - - - + -
CD40 Variability + + + + + + + + ++ ++ + ++ + + + + + + ++ +

Limitations and Warranty

enQuire Bio's CD40 / TNFRSF5 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-CD40 / TNFRSF5 Antibody Clone C40/1605

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