Immunohistochemical staining of CD45 of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

CD45 [EP68] Antibody (cGMP).

Name: CD45 [EP68] Antibody (cGMP).
Brand: enQuire Bio
Price: 135 USD
Availability: InStock

$ 135.00 – $ 745.00

Please Select Product Options Below To View The Catalog Number.

SKU: QIVD247
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Rabbit Rabbit IgG

Product Number	Description	Price
QIVD247-0.1ml	Size: 0.1 ml, Format: Concentrate	$ 135.00
QIVD247-0.5ml	Size: 0.5 ml, Format: Concentrate	$ 465.00
QIVD247-1ml	Size: 1 ml, Format: Concentrate	$ 745.00
QIVD247-6ml	Size: 6 ml, Format: Predilute	$ 355.00

Shipping Information

In Stock

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QIVD247-0.1ml

CD45 General Information
Alternate Names

Molecular Weight
147.5 kDa
Chromosomal Location
q31.3 [chr: 1] [chr_start: 198638457] [chr_end: 198757476] [strand: 1]; [chr: CHR_HSCHR1_3_CTG31] [chr_start: 198650158] [chr_end: 198733963] [strand: 1]
Curated Database and Bioinformatic Data
Gene Symbol	PTPRC
Entrez Gene ID	5788
RefSeq Protein Accession(s)	XP_006711536; NP_002829; XP_006711535; NP_563578; XP_006711537
RefSeq mRNA Accession(s)	; XM_006711473; XM_006711474; NM_080921; NM_080922; NM_001267798; NM_002838; XM_006711472; NR_052021
RefSeq Genomic Accession(s)	NG_007730; NC_000001; NW_003315907
UniProt ID(s)	P08575
PharmGKB ID(s)	PA34011
KEGG Gene ID(s)	hsa:5788
Associated Diseases (KEGG IDs)	Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. {ECO:0000269\|PubMed:11145714}. The disease is caused by mutations affecting the gene represented in this entry.; Multiple sclerosis (MS) [MIM:126200]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. {ECO:0000269\|PubMed:11101853}. Disease susceptibility may be associated with variations affecting the gene represented in this entry.
General Description of CD45 .
CD45, also known as the leukocyte common antigen (LCA), is a transmembrane protein-tyrosine phosphatase (PTPase) that is expressed in almost all ematolymphoid cells including lymphocytes, granulocytes, monocytes and macrophage, but not in mature erythrocytes and megakaryocytes. CD45 antibody labelling of majority of hematolymphoid neoplasms, is a first line of marker for the identification of tumors with hematopoietic origin. Rare cases of undifferentiated and neuroendocrine carcinomas with CD45 positive staining have been reported.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.

Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.

Application Notes

Specification	Recommendation
Recommended Dilution (Conc)	1:50-1:100
Pretreatment	Citrate Buffer pH 6.0
Incubation Parameters	30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal

Anti-CD45 Antibody Clone: EP68

Host and Isotype: Rabbit Rabbit IgG

Recommended Positive Control Sample: Tonsil, Lymphoma

Cellular Localization of Antibody EP68 Staining: Cytoplasmic, cell membrane

Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN₃

Antibody Concentration: Lot specific. Plese contact tech support for data.

Immunogen: A synthetic peptide corresponding to residues in the C-terminal domain of human CD45 protein

Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

CD45 Information for Pathologists

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

There are no reviews yet.