Formalin-fixed, paraffin-embedded human Testis stained with gp1 / Melanosome Monoclonal Antibody (HMB45).

Anti-gp100 / Melanosome / PMEL17 / SILV Antibody Clone HMB45

Name: Anti-gp100 / Melanosome / PMEL17 / SILV Antibody Clone HMB45
Brand: enQuire Bio
Price: 429 USD
Availability: InStock

$ 429.00

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SKU: 6490-MSM1
Species: Human, Canine (-), and Rat (-)
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product Number	Description	Price
6490-MSM1-P1	Size: 100 ug, Tag: Unconjugated

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In Stock.

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Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: 6490-MSM1-P1

gp100 / Melanosome / PMEL17 / SILV General Information
Alternate Names
Melanocyte protein PMEL, Premelanosome protein, PMEL, Silver locus protein homolog, SILV
Molecular Weight
90-100kDa
Chromosomal Location
12q13.2
Curated Database and Bioinformatic Data
Gene Symbol	SILV
Entrez Gene ID	6490
Ensemble Gene ID	ENSG00000185664
RefSeq Protein Accession(s)	NP_001186982, XP_006719632, NP_001307050, NP_008859, XP_011536987, NP_001186983, NP_001307051
RefSeq mRNA Accession(s)	XM_006719569, NM_001320122, NM_001200053, XM_011538685, NM_001320121, NM_006928 NM_001200054
RefSeq Genomic Accession(s)	NC_000012, NC_018923, NG_028086
UniProt ID(s)	P40967
UniGene ID(s)	P40967
HGNC ID(s)	10880
Cosmic ID(s)	PMEL
KEGG Gene ID(s)	hsa:6490
PharmGKB ID(s)	PA35781
General Description of gp100 / Melanosome / PMEL17 / SILV.
By immunohistochemistry, it specifically recognizes a protein in melanocytes, melanomas. This MAb reacts with junctional, blue nevus cells, variably with fetal, neonatal melanocytes. Intradermal nevi, normal adult melanocytes,, non-melanocytic cells are negative. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin. Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas, large cell lymphomas,, sarcomas using H & E stains alone. It is also difficult to differentiate melanoma from spindle cell carcinomas, various types of mesenchymal neoplasms. This MAb stains fetal, neonatal melanocytes, junctional, blue nevus cells,, malignant melanoma. This MAb also stains Angiomyolipoma (PEComa).

Human, Canine (-), and Rat (-) Anti-gp100 / Melanosome / PMEL17 / SILV Antibody Product Attributes

Species: Human, Canine (-), and Rat (-)

Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).

Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (0.5-1ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1.0ug of antibody/ml for 30 minutes at RT)

Clonality: Monoclonal

Anti-gp100 / Melanosome / PMEL17 / SILV Antibody Clone: HMB45

Clone HMB45 Host and Isotype: Mouse IgG1 kappa

Anti-Human, Canine (-), and Rat (-) gp100 / Melanosome / PMEL17 / SILV Positive Control Sample: SK-MEL-28 cells or Melanoma

Cellular Localization of Antibody Cytoplasmic

Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.

Antibody Concentration: 200ug/ml

Antibody Purification Method:Protein A/G Purified

Immunogen: Extract of pigmented melanoma metastases from lymph nodes

Storage Conditions: Store at 2 to 8Â° C (refrigerate). Stable for 24 months when properly stored.

gp100 / Melanosome / PMEL17 / SILV Previously Observed Antibody Staining Patterns

Limitations and Warranty

enQuire Bio's gp100 / Melanosome / PMEL17 / SILV Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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