Analysis of Mass Spec data (dashed-line) of fractions stained with Moesin MS-QAVA™ monoclonal antibody [Clone: MSN/491] (solid-line), reveals that less than 0.8% of signal is attributable to non-specific binding of anti-Moesin [Clone: MSN/491] to targets other than MSN protein. Even frequently cited antibodies have much greater non-specific interactions, averaging over 30%. Data in image is from analysis in A431, RT4 and MCF7 cells.

Anti-Moesin Antibody Clone MSN/491

$ 199.00$ 459.00
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SKU: 4478-MSM1
Species: Human and Rat
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: MS-QAVA™ Validated

Product NumberDescriptionPrice
4478-MSM1-P0 Size: 20 ug, Tag: Unconjugated $ 199.00
4478-MSM1-P1 Size: 100 ug, Tag: Unconjugated $ 429.00
4478-MSM1-P2 Size: 200 ug, Tag: Unconjugated $ 459.00
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SKU: 4478-MSM1-P0
Moesin General Information
Alternate Names
HEL70, Moesin
Molecular Weight
Chromosomal Location
Curated Database and Bioinformatic Data
Gene SymbolMSN
Entrez Gene ID4478
Ensemble Gene IDENSG00000147065
RefSeq Protein Accession(s)XP_005262326, XP_011529261, XP_016885034, XP_016885035, NP_002435
RefSeq mRNA Accession(s)XM_005262269, XM_017029546, XM_017029545, XM_011530959 NM_002444
RefSeq Genomic Accession(s)NC_018934, NG_012516, NC_000023
UniProt ID(s)V9HWC0, P26038
UniGene ID(s)V9HWC0, P26038
HGNC ID(s)7373
Cosmic ID(s)MSN
KEGG Gene ID(s)hsa:4478
PharmGKB ID(s)PA31178
General Description of Moesin.
Recognizes 78kDa moesin protein. Moesin, a member of the talin-4.1 superfamily, is a linking protein of the sub-membranous actin cytoskeleton. It is expressed in variable amounts in cells of different phenotypes such as macrophages, lymphocytes, fibroblastic, endothelial, epithelial, and neuronal cell lines but not in blood cells. The ERM proteins, ezrin, radixin, and moesin are involved in a variety of cellular functions, such as cell adhesion, migration, and the organization of cell surface structures, and are highly homologous, both in protein sequence and in functional activity, with merlin/schwannomin, a neurofibromatosis-2-associated tumor-suppressor protein. Cell lines of epithelial and mesothelial origin contain both moesin and radixin whereas cells of endothelial and lymphoid origin express moesin.

Human and Rat Anti-Moesin Antibody Product Attributes

Species: Human and Rat
Tested Applications: Immunohistochemistry (IHC). Additionally, this antibody has been validated by MS-QAVA™. Specificity has been quantitatively determined via Mass Spec.
Clonality: Monoclonal
Anti-Moesin Antibody Clone: MSN/491
Clone MSN/491 Host and Isotype: Mouse IgG1 kappa
Anti-Human and Rat Moesin Positive Control Sample: HT-29, CH3LC, or HUVEC cells. Uterus, Placenta, Tonsil, Melanoma, Testicular Carcinoma.
Cellular Localization of Antibody Cytoplasmic, Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant full-length human Moesin protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Moesin Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Variations in Moesin antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in hematopoietic cells in the bone marrow, germinal center cells in the lymph node and tonsil and non-germinal center cells in the tonsil. More moderate antibody staining intensity was present in hematopoietic cells in the bone marrow, germinal center cells in the lymph node and tonsil and non-germinal center cells in the tonsil. Low, but measureable presence of Moesin could be seen inglandular cells in the breast, cells in the molecular layer in cerebellum, glial cells in the cerebral cortex, glandular cells in the cervix, uterine, squamous epithelial cells in the cervix, uterine, cells in the endometrial stroma in endometrium, glandular cells in the endometrium and fallopian tube, follicle cells in the ovary, ovarian stroma cells in the ovary, exocrine glandular cells in the pancreas, glandular cells in the parathyroid gland, prostate and seminal vesicle, fibroblasts in skin, keratinocytes in skin, melanocytes in skin, smooth muscle cells in the smooth muscle, cells in the seminiferous ducts in testis, glandular cells in the thyroid gland and urothelial cells in the urinary bladder. We were unable to detect Moesin in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Type:

Tissues from cancer patients, for instance, have their own distinct pattern of Moesin expression as measured by anti-Moesin antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - ++ - + - +++ + ++ +++ ++ + ++ - ++ ++ - + +++ -
MSN Variability + ++ ++ + ++ ++ ++ ++ ++ ++ + ++ ++ + ++ ++ ++ ++ ++ ++

Limitations and Warranty

This product is for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-Moesin Antibody Clone MSN/491