Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with MUC5AC Monoclonal Antibody (SPM297).
Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with MUC5AC Monoclonal Antibody (SPM297).

Anti-MUC5AC Antibody Clone SPM297

$ 298.00
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SKU: 4586-MSM1X
Species: Human, Monkey, Rabbit, Cat, Mouse, Rat, Pig, Chicken, and Cow (-)
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
4586-MSM1X-P1 Size: 100 ug, Tag: Unconjugated
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SKU: 4586-MSM1X-P1
MUC5AC General Information
Alternate Names
Mucin 5AC, Muc5AC, MUC5AC
Molecular Weight
>1,000kDa
Chromosomal Location
11p15.5
Curated Database and Bioinformatic Data
Gene SymbolMUC5AC
Entrez Gene ID4586
Ensemble Gene IDENSG00000215182, ENSG00000283158
RefSeq Protein Accession(s)NP_001291288
RefSeq mRNA Accession(s)NM_017511, NM_001304359
RefSeq Genomic Accession(s)NW_015148966, NC_000011, NC_018922
UniProt ID(s)P98088, Q7M4S5
UniGene ID(s)P98088, Q7M4S5
HGNC ID(s)7515
Cosmic ID(s)MUC5AC
KEGG Gene ID(s)hsa:4586
PharmGKB ID(s)PA31321
General Description of MUC5AC.
This MAb recognizes the peptide core of gastric mucin M1 (>1,000kDa) (recently identified as Mucin 5AC). Its epitope is destroyed by beta-mercaptoethanol, proteases but not by periodate treatment. Antibody to gastric mucin M1 reacts with the gastric epithelium of normal human gastrointestinal tract as well as with the precancerous, cancerous colon but not with normal adult colon. It also reacts with fetal colonic mucosa. Resurgence of gastric mucin reactivity during colonic carcinogenesis is due to re-expression of the peptide core of gastric (or fetal colonic) mucins.

Human, Monkey, Rabbit, Cat, Mouse, Rat, Pig, Chicken, and Cow (-) Anti-MUC5AC Antibody Product Attributes

Species: Human, Monkey, Rabbit, Cat, Mouse, Rat, Pig, Chicken, and Cow (-)
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (1-2ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-MUC5AC Antibody Clone: SPM297
Clone SPM297 Host and Isotype: Mouse IgG1 kappa
Anti-Human, Monkey, Rabbit, Cat, Mouse, Rat, Pig, Chicken, and Cow (-) MUC5AC Positive Control Sample: Stomach
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b) patient
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

MUC5AC Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in MUC5AC antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in respiratory epithelial cells in the bronchus, glandular cells in the cervix, uterine, respiratory epithelial cells in the nasopharynx and glandular cells in the stomach. More moderate antibody staining intensity was present in respiratory epithelial cells in the bronchus, glandular cells in the cervix, uterine, respiratory epithelial cells in the nasopharynx and glandular cells in the stomach. Low, but measureable presence of MUC5AC could be seen in. We were unable to detect MUC5AC in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's MUC5AC Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-MUC5AC Antibody Clone SPM297

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