Western Blot Analysis (A) Recombinant Protein (B) THP1 Cell lysate Using Thrombomodulin/CD141 Monoclonal Antibody (THBD/1591).
Western Blot Analysis (A) Recombinant Protein (B) THP1 Cell lysate Using Thrombomodulin/CD141 Monoclonal Antibody (THBD/1591).Formalin-fixed, paraffin-embedded human Bladder Carcinoma stained with Thrombomodulin Monoclonal/CD141 Antibody (THBD/1591).Formalin-fixed, paraffin-embedded human Placenta stained with Thrombomodulin/CD141 Monoclonal Antibody (THBD/1591).

Anti-Thrombomodulin / CD141 Antibody Clone THBD/1591

$ 228.00$ 518.00
Please Select Product Options Below To View The Catalog Number.

SKU: 7056-MSM1
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG2b kappa
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
7056-MSM1-P0 Size: 20 ug, Tag: Unconjugated $ 228.00
7056-MSM1-P1 Size: 100 ug, Tag: Unconjugated $ 488.00
7056-MSM1-P2 Size: 200 ug, Tag: Unconjugated $ 518.00
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In Stock.
Flat Rate Shipping Anywhere in the US: $45
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SKU: 7056-MSM1-P0
Thrombomodulin / CD141 General Information
Alternate Names
Thrombomodulin, TM, CD141, BDCA-3
Molecular Weight
100kDa
Chromosomal Location
20p11.2
Curated Database and Bioinformatic Data
Gene SymbolTHBD
Entrez Gene ID7056
Ensemble Gene IDENSG00000178726
RefSeq Protein Accession(s)NP_000352
RefSeq mRNA Accession(s)NM_000361
RefSeq Genomic Accession(s)NC_018931, NC_000020, NG_012027
UniProt ID(s)P07204
UniGene ID(s)P07204
HGNC ID(s)11784
Cosmic ID(s)THBD
KEGG Gene ID(s)hsa:7056
PharmGKB ID(s)PA36496
General Description of Thrombomodulin / CD141.
This MAb recognizes a protein of 75kDa, identified as Thrombomodulin. Thrombomodulin is a transmembrane glycoprotein with natural anticoagulant properties. It is normally expressed by a restricted number of cells, such as endothelial and mesothelial cells. In addition, synovial lining and syncytio-trophoblasts of placenta also express thrombomodulin. This protein is present in almost all of benign vascular tumors and majority of malignant vascular tumors (Kaposi s sarcoma, angiosarcoma, and epithelioid hemangioendothelioma). Hence, anti-thrombomodulin serves as a sensitive marker for lymphatic endothelial cells and their tumors. Recently, thrombomodulin antibody has been used for mesothelial cells and malignant mesotheliomas.

Human Anti-Thrombomodulin / CD141 Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Thrombomodulin / CD141 Antibody Clone: THBD/1591
Clone THBD/1591 Host and Isotype: Mouse IgG2b kappa
Anti-Human Thrombomodulin / CD141 Positive Control Sample: THP1 Cells. Placenta, Angiosarcoma, Bladder or Cervical Carcinoma
Cellular Localization of Antibody Cell Surface ;Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human Thrombomodulin protein fragment (aa69-194)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

Thrombomodulin / CD141 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-THBD antibody staining is expected to be primarily localized to the cytosol and nucleoplasm.

Observed Antibody Staining Data By Tissue Type:

Variations in Thrombomodulin / CD141 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of Thrombomodulin / CD141 could be seen innon-germinal center cells in the lymph node and squamous epithelial cells in the tonsil. We were unable to detect Thrombomodulin / CD141 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of Thrombomodulin / CD141 expression as measured by anti-Thrombomodulin / CD141 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - ++ - - - + - - - - - - - - ++ - - - -
THBD Variability ++ ++ ++ + + + ++ + + + + + + ++ + ++ + + + ++

Limitations and Warranty

enQuire Bio's Thrombomodulin / CD141 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-Thrombomodulin / CD141 Antibody Clone THBD/1591

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