Recombinant Mouse CXCL12 / SDF-1 Protein

$ 98.00 – $ 1,838.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP10259
Species: Mouse
Available Tags: Untagged
Host: E. coli
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Length (Amino Acids): 72

Product Number	Description	Price
QP10259-ec-10ug	Size: 10 ug, Tag: Untagged (Native Protein)	$ 248.00
QP10259-ec-100ug	Size: 100 ug, Tag: Untagged (Native Protein)	$ 1,018.00
QP10259-ec-250ug	Size: 250 ug, Tag: Untagged (Native Protein)	$ 1,838.00
QP10259-ec-2ug	Size: 2 ug, Tag: Untagged (Native Protein)	$ 98.00

Shipping Information

7-10 days

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP10259-ec-10ug

Recombinant Mouse CXCL12 / SDF-1 Protein General Information
Alternate Names
CXCL12; SDF-1; SCYB12; IRH; PBSF; SDF1; TPAR1; TLSF
Curated Database and Bioinformatic Data
Gene Symbol	CXCL12
Entrez Gene ID	20315
Ensemble Gene ID	ENSMUSG00000061353
RefSeq Protein Accession(s)	NP_038683.1
RefSeq mRNA Accession(s)	NM_013655.4, NM_021704.3
UniProt ID(s)	P40224
UniGene ID(s)	Mm.303231
COSMIC ID Link(s)	CXCL12
KEGG Gene ID(s)	mmu:20315
General Description of Recombinant Mouse CXCL12 / SDF-1 Protein.
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells (By similarity). Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. ; Stimulates the proliferation of bone marrow-derived b progenitor cells in the presence of IL-7 as well as growth of the stromal cell-dependent B-cell clone DW34 cells.

Mouse CXCL12 / SDF-1 Bioactive Protein Product Attributes

Product Type: Bioactive Protein

Recombinant CXCL12 / SDF-1 based upon sequence from: Mouse

Host: QP10259 protein expressed in E. coli.

Tag: Untagged

Protein Construction: A DNA sequence encoding the Mouse CXCL12 / SDF-1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Application Notes: Please contact us for application specific information for QP10259.

Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 50-100 ng/ml.

Full Length? Partial (see sequence information for more details).

Amino Acid Sequence: KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKRL KM

Purity: Greater than 97% as determined by SDS-PAGE and HPLC.

Reconstitution Instructions:

Concentration of Mouse CXCL12 / SDF-1 Protein: Lyophilized. Concentration determined by reconstitution volume.

Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.

Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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