Recombinant Human IL36G / IL1F9 Protein

$ 98.00$ 3,188.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP10341
Species: Human
Available Tags: Untagged
Host: E. coli
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Length (Amino Acids): 169

Product NumberDescriptionPrice
QP10341-ec-10ug Size: 10 ug, Tag: Untagged (Native Protein) $ 278.00
QP10341-ec-100ug Size: 100 ug, Tag: Untagged (Native Protein) $ 1,998.00
QP10341-ec-250ug Size: 250 ug, Tag: Untagged (Native Protein) $ 3,578.00
QP10341-ec-2ug Size: 2 ug, Tag: Untagged (Native Protein) $ 108.00
Shipping Information
7-10 days
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP10341-ec-10ug
Recombinant Human IL36G / IL1F9 Protein General Information
Alternate Names
IL36G; IL1F9; IL-1RP2; IL-1H1; IL1H1; IL1E; IL1F9; IL1RP2; IL-1F9
Curated Database and Bioinformatic Data
Gene SymbolIL36G
Entrez Gene ID56300
Ensemble Gene IDENSG00000136688
RefSeq Protein Accession(s)NP_001265497.1
RefSeq mRNA Accession(s)NM_001278568.1, NM_019618.3
UniProt ID(s)Q9NZH8
UniGene ID(s)Hs.211238
HGNC ID(s)HGNC:15741
COSMIC ID Link(s)IL36G
KEGG Gene ID(s)hsa:56300
PharmGKB ID(s)PA38395
General Description of Recombinant Human IL36G / IL1F9 Protein.
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.

Human IL36G / IL1F9 Bioactive Protein Product Attributes

Product Type: Bioactive Protein
Recombinant IL36G / IL1F9 based upon sequence from: Human
Host: QP10341 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human IL36G / IL1F9, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10341.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The specific activity is determined by its binding ability in a functional ELISA. Immobilized rHuIL-36gamma at 1 ug/mL can bind recombinant human IL-1 Rrp2 Fc Chimera with a range of 0.15-5 ug/mL.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: MRGTPGDADG GGRAVYQSMC KPITGTINDL NQQVWTLQGQ NLVAVPRSDS VTPVTVAVIT CKYPEALEQG RGDPIYLGIQ NPEMCLYCEK VGEQPTLQLK EQKIMDLYGQ PEPVKPFLFY RAKTGRTSTL ESVAFPDWFI ASSKRDQPII LTSELGKSYN TAFELNIND
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human IL36G / IL1F9 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human IL36G / IL1F9 Protein