Recombinant Human TRAIL R2 / CD262 / TNFRSF10B Protein

$ 98.00$ 918.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP10367
Species: Human
Available Tags: Untagged
Host: E. coli
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Length (Amino Acids): 132

Product NumberDescriptionPrice
QP10367-ec-10ug Size: 10 ug, Tag: Untagged (Native Protein) $ 98.00
QP10367-ec-50ug Size: 50 ug, Tag: Untagged (Native Protein) $ 248.00
QP10367-ec-100ug Size: 100 ug, Tag: Untagged (Native Protein) $ 508.00
QP10367-ec-250ug Size: 250 ug, Tag: Untagged (Native Protein) $ 918.00
Shipping Information
7-10 days
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP10367-ec-10ug
Recombinant Human TRAIL R2 / CD262 / TNFRSF10B Protein General Information
Alternate Names
TRAIL R2; CD262; TNFRSF10B; TRICKB; TRAIL-R2; CD262; TRAILR2; KILLER; KILLER/DR5; TRICK2A; TRICK2B; ZTNFR9; DR5; TRICK2
Curated Database and Bioinformatic Data
Gene SymbolTNFRSF10B
Entrez Gene ID8795
Ensemble Gene IDENSG00000120889
RefSeq Protein Accession(s)NP_003833.4
RefSeq mRNA Accession(s)NM_003842.4, NM_147187.2
UniProt ID(s)O14763
HGNC ID(s)HGNC:11905
COSMIC ID Link(s)TNFRSF10B
KEGG Gene ID(s)hsa:8795
PharmGKB ID(s)PA36598
General Description of Recombinant Human TRAIL R2 / CD262 / TNFRSF10B Protein.
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

Human TRAIL R2 / CD262 / TNFRSF10B Bioactive Protein Product Attributes

Product Type: Bioactive Protein
Recombinant TRAIL R2 / CD262 / TNFRSF10B based upon sequence from: Human
Host: QP10367 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human TRAIL R2 / CD262 / TNFRSF10B, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10367.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. rHusTRAIL-R2 reduced the production of LPS- induced TNF by its ability to neutralize endogenous TRAIL in fresh human PBMC. In this assay, endogenous TRAIL is induced during a 24 hour exposure to LPS (10 ng/mL) but in the presence of rHusTRAIL-R2, TRAIL-induced TNF is suppressed.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: ESALITQQDL APQQRAAPQQ KRSSPSEGLC PPGHHISEDG RDCISCKYGQ DYSTHWNDLL FCLRCTRCDS GEVELSPCTT TRNTVCQCEE GTFREEDSPE MCRKCRTGCP RGMVKVGDCT PWSDIECVHK ES
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human TRAIL R2 / CD262 / TNFRSF10B Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human TRAIL R2 / CD262 / TNFRSF10B Protein