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QP10373 TNFSF18
QP10373 TNFSF18

Recombinant Human TNFSF18 Protein

$ 98.00 – $ 2,478.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP10373
Species: Human
Available Tags: Untagged
Host: E. coli
Purity: Greater than 98% as determined by SDS-PAGE and HPLC.
Length (Amino Acids): 126

Product NumberDescriptionPrice
QP10373-ec-5ug Size: 5 ug, Tag: Untagged (Native Protein) $ 98.00
QP10373-ec-20ug Size: 20 ug, Tag: Untagged (Native Protein) $ 248.00
QP10373-ec-100ug Size: 100 ug, Tag: Untagged (Native Protein) $ 1,158.00
QP10373-ec-250ug Size: 250 ug, Tag: Untagged (Native Protein) $ 2,478.00
Shipping Information
7-10 days
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP10373-ec-5ug
Recombinant Human TNFSF18 Protein General Information
Alternate Names
TL6; GITRL; AITRL; TNLG2A; hGITRL; Tumor necrosis factor ligand superfamily member
Curated Database and Bioinformatic Data
Gene SymbolTNFSF18
Entrez Gene ID8995
Ensemble Gene IDENSG00000120337
RefSeq Protein Accession(s)NP_005083.2
RefSeq mRNA Accession(s)NM_005092.3
UniProt ID(s)Q9UNG2
HGNC ID(s)HGNC:11932
COSMIC ID Link(s)TNFSF18
KEGG Gene ID(s)hsa:8995
PharmGKB ID(s)PA36624
General Description of Recombinant Human TNFSF18 Protein.
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).

Human TNFSF18 Bioactive Protein Product Attributes

Product Type: Bioactive Protein
Recombinant TNFSF18 based upon sequence from: Human
Host: QP10373 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human TNFSF18, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10373.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The biological activity as determined by stimulation of IL-8 production using human PBMC is in a concentration range of 0.1-10 ng/ml.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: ETAKEPCMAK FGPLPSKWQM ASSEPPCVNK VSDWKLEILQ NGLYLIYGQV APNANYNDVA PFEVRLYKNK DMIQTLTNKS KIQNVGGTYE LHVGDTIDLI FNSEHQVLKN NTYWGIILLA NPQFIS
Purity: Greater than 98% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human TNFSF18 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 m filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human TNFSF18 Protein

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