Recombinant Human NRG1 Protein

$ 108.00$ 1,028.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP10414
Species: Human
Available Tags: Untagged
Host: E. coli
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Length (Amino Acids): 65

Product NumberDescriptionPrice
QP10414-ec-50ug Size: 50 ug, Tag: Untagged (Native Protein) $ 248.00
QP10414-ec-100ug Size: 100 ug, Tag: Untagged (Native Protein) $ 508.00
QP10414-ec-250ug Size: 250 ug, Tag: Untagged (Native Protein) $ 918.00
QP10414-ec-10ug Size: 10 ug, Tag: Untagged (Native Protein) $ 98.00
Shipping Information
7-10 days
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP10414-ec-50ug
Recombinant Human NRG1 Protein General Information
Alternate Names
NRG1; GGF; GGF2; HGL; HRGA; MSTP131; NDF; HRG; HRG1; MST131; NRG1-IT2; ARIA; SMDF
Curated Database and Bioinformatic Data
Gene SymbolNRG1
Entrez Gene ID3084
Ensemble Gene IDENSG00000157168
RefSeq Protein Accession(s)NP_001153467.1
RefSeq mRNA Accession(s)NM_001159995.2, NM_001159999.2, NM_001160001.2, NM_001160005.1, NM_001160008.1, NM_001322205.1, NM_001322206.1, NM_001322207.1, NM_013956.4, NM_013957.4, NM_013958.3, NM_013959.3, NM_013960.4, NM_013962.2, NM_013964.4
UniProt ID(s)Q02297
HGNC ID(s)HGNC:7997
COSMIC ID Link(s)NRG1
KEGG Gene ID(s)hsa:3084
PharmGKB ID(s)PA31776
General Description of Recombinant Human NRG1 Protein.
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

Human NRG1 Bioactive Protein Product Attributes

Product Type: Bioactive Protein
Recombinant NRG1 based upon sequence from: Human
Host: QP10414 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human NRG1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10414.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using serum free human MCF-7 cells is less than 0.5 ng/ml, corresponding to a specific activity of > 2.0 × 106 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human NRG1 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 m filtered 1 × PBS, pH 7.4, with 5 % trehalose, lyophilized
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human NRG1 Protein

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