Recombinant Human Midkine / MDK Protein

$ 98.00 – $ 1,838.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP10419
Species: Human
Available Tags: Untagged
Host: E. coli
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Length (Amino Acids): 123

Product Number	Description	Price
QP10419-ec-5ug	Size: 5 ug, Tag: Untagged (Native Protein)	$ 108.00
QP10419-ec-20ug	Size: 20 ug, Tag: Untagged (Native Protein)	$ 278.00
QP10419-ec-100ug	Size: 100 ug, Tag: Untagged (Native Protein)	$ 1,148.00
QP10419-ec-250ug	Size: 250 ug, Tag: Untagged (Native Protein)	$ 2,058.00

Shipping Information

7-10 days

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP10419-ec-5ug

Recombinant Human Midkine / MDK Protein Protein General Information
Alternate Names
Midkine; MDK Protein; MK; NEGF2; ARAP
Curated Database and Bioinformatic Data
Gene Symbol	MDK
Entrez Gene ID	4192
Ensemble Gene ID	ENSG00000110492
RefSeq Protein Accession(s)	NP_001012333.1
RefSeq mRNA Accession(s)	NM_001012333.2, NM_001012334.2, NM_001270550.1, NM_001270551.1, NM_001270552.1, NM_002391.4, XM_011520116.2, XM_017017764.1
UniProt ID(s)	P21741
UniGene ID(s)	Hs.82045
HGNC ID(s)	HGNC:6972
COSMIC ID Link(s)	MDK
KEGG Gene ID(s)	hsa:4192
PharmGKB ID(s)	PA30717
General Description of Recombinant Human Midkine / MDK Protein Protein.
Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity).

Human Midkine / MDK Protein Bioactive Protein Product Attributes

Product Type: Bioactive Protein

Recombinant Midkine / MDK Protein based upon sequence from: Human

Host: QP10419 protein expressed in E. coli.

Tag: Untagged

Protein Construction: A DNA sequence encoding the Human Midkine / MDK Protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Application Notes: Please contact us for application specific information for QP10419.

Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration range of 0.1-10 ng/ml.

Full Length? Partial (see sequence information for more details).

Amino Acid Sequence: VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI RVTKPCTPKT KAKAKAKKGK GKD

Purity: Greater than 97% as determined by SDS-PAGE and HPLC.

Reconstitution Instructions:

Concentration of Human Midkine / MDK Protein Protein: Lyophilized. Concentration determined by reconstitution volume.

Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.

Buffer: 0.2 um filtered PBS, pH7.4, lyophilized

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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