Recombinant Mouse IL-11 / interleukin 11 Protein

$ 98.00 – $ 3,188.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP10459
Species: Mouse
Available Tags: Untagged
Host: E. coli
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Length (Amino Acids): 179

Product Number	Description	Price
QP10459-ec-2ug	Size: 2 ug, Tag: Untagged (Native Protein)	$ 98.00
QP10459-ec-10ug	Size: 10 ug, Tag: Untagged (Native Protein)	$ 248.00
QP10459-ec-100ug	Size: 100 ug, Tag: Untagged (Native Protein)	$ 1,778.00
QP10459-ec-250ug	Size: 250 ug, Tag: Untagged (Native Protein)	$ 3,188.00

Shipping Information

7-10 days

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP10459-ec-2ug

Recombinant Mouse IL-11 / interleukin 11 Protein General Information
Alternate Names
IL-11; interleukin 11; AGIF; IL-11
Curated Database and Bioinformatic Data
Gene Symbol	IL11
Entrez Gene ID	16156
Ensemble Gene ID	ENSMUSG00000004371
RefSeq Protein Accession(s)	NP_032376.1
RefSeq mRNA Accession(s)	NM_008350.4
UniProt ID(s)	P47873
UniGene ID(s)	Mm.35814
COSMIC ID Link(s)	IL11
KEGG Gene ID(s)	mmu:16156
General Description of Recombinant Mouse IL-11 / interleukin 11 Protein.
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:8913282). Also promotes the proliferation of hepatocytes in response to liver damage (PubMed:22253262). Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers (PubMed:10026196, PubMed:23948300). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3 (PubMed:23948300, PubMed:22253262).

Mouse IL-11 / interleukin 11 Bioactive Protein Product Attributes

Product Type: Bioactive Protein

Recombinant IL-11 / interleukin 11 based upon sequence from: Mouse

Host: QP10459 protein expressed in E. coli.

Tag: Untagged

Protein Construction: A DNA sequence encoding the Mouse IL-11 / interleukin 11, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Application Notes: Please contact us for application specific information for QP10459.

Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using murine T11 cells is less than 2 ng/ml, corresponding to a specific activity of > 5.0 Ã 105 IU/mg.

Full Length? Partial (see sequence information for more details).

Amino Acid Sequence: MPGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM RDKFPADGDH SLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYLRHVQW LRRAGGPSLK TLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPVIP LGPPASAWGS IRAAHAILGG LHLTLDWAVR GLLLLKTRL

Purity: Greater than 97% as determined by SDS-PAGE and HPLC.

Reconstitution Instructions:

Concentration of Mouse IL-11 / interleukin 11 Protein: Lyophilized. Concentration determined by reconstitution volume.

Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.

Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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