Recombinant Mouse IL-11 / interleukin 11 Protein

$ 98.00$ 3,188.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP10459
Species: Mouse
Available Tags: Untagged
Host: E. coli
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Length (Amino Acids): 179

Product NumberDescriptionPrice
QP10459-ec-2ug Size: 2 ug, Tag: Untagged (Native Protein) $ 98.00
QP10459-ec-10ug Size: 10 ug, Tag: Untagged (Native Protein) $ 248.00
QP10459-ec-100ug Size: 100 ug, Tag: Untagged (Native Protein) $ 1,778.00
QP10459-ec-250ug Size: 250 ug, Tag: Untagged (Native Protein) $ 3,188.00
Shipping Information
7-10 days
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP10459-ec-2ug
Recombinant Mouse IL-11 / interleukin 11 Protein General Information
Alternate Names
IL-11; interleukin 11; AGIF; IL-11
Curated Database and Bioinformatic Data
Gene SymbolIL11
Entrez Gene ID16156
Ensemble Gene IDENSMUSG00000004371
RefSeq Protein Accession(s)NP_032376.1
RefSeq mRNA Accession(s)NM_008350.4
UniProt ID(s)P47873
UniGene ID(s)Mm.35814
COSMIC ID Link(s)IL11
KEGG Gene ID(s)mmu:16156
General Description of Recombinant Mouse IL-11 / interleukin 11 Protein.
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:8913282). Also promotes the proliferation of hepatocytes in response to liver damage (PubMed:22253262). Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers (PubMed:10026196, PubMed:23948300). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3 (PubMed:23948300, PubMed:22253262).

Mouse IL-11 / interleukin 11 Bioactive Protein Product Attributes

Product Type: Bioactive Protein
Recombinant IL-11 / interleukin 11 based upon sequence from: Mouse
Host: QP10459 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Mouse IL-11 / interleukin 11, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10459.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using murine T11 cells is less than 2 ng/ml, corresponding to a specific activity of > 5.0 × 105 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: MPGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM RDKFPADGDH SLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYLRHVQW LRRAGGPSLK TLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPVIP LGPPASAWGS IRAAHAILGG LHLTLDWAVR GLLLLKTRL
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Mouse IL-11 / interleukin 11 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Mouse IL-11 / interleukin 11 Protein