SDS-PAGE separation of QP8573 followed by commassie total protein stain results in a primary band consistent with reported data for TNF-alpha. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human TNF-alpha Protein

$ 88.00$ 1,138.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8573
Species: Human
Available Tags: His
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 157

Size
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Shipping Information
4-6 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP8573-ec-10ug
Recombinant Human TNF-alpha Protein General Information
Alternate Names
TNF-alpha; TNF-a; Cachectin; TNFSF2; TNF-alpha; TNFA
Curated Database and Bioinformatic Data
Gene SymbolTNF
Entrez Gene ID7124
Ensemble Gene IDENSG00000204490
RefSeq Protein Accession(s)NP_000585.2
RefSeq mRNA Accession(s)NM_000594.3
UniProt ID(s)P01375
UniGene ID(s)Hs.241570
HGNC ID(s)HGNC:11892
COSMIC ID Link(s)TNF
KEGG Gene ID(s)hsa:7124
PharmGKB ID(s)PA435
General Description of Recombinant Human TNF-alpha Protein.
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective .

Human TNF-alpha Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant TNF-alpha based upon sequence from: Human
Host: QP8573 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TNF-alpha, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8573.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Val77 - Leu2
Amino Acid Sequence: VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV YFGIIAL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human TNF-alpha Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human TNF-alpha Protein