Recombinant Human Ephrin-A1 / EFNA1 Protein

$ 398.00 – $ 1,728.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP5963
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His-SUMO
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 164

Product Number	Description	Price
QP5963-ec-100ug	Size: 100 ug, Tag: His-SUMO	$ 398.00
QP5963-ec-1mg	Size: 1 mg, Tag: His-SUMO	$ 1,728.00

Shipping Information

2-4 weeks

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Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP5963-ec-10ug

Recombinant Human Ephrin-A1 / EFNA1 Protein General Information
Curated Database and Bioinformatic Data
Gene Symbol	EFNA1
Entrez Gene ID	1942
Ensemble Gene ID	ENSG00000169242
RefSeq Protein Accession(s)	NP_004419.2
RefSeq mRNA Accession(s)	NM_004428.2, NM_182685.1
UniProt ID(s)	P20827
UniGene ID(s)	Hs.516664
HGNC ID(s)	HGNC:3221
COSMIC ID Link(s)	EFNA1
KEGG Gene ID(s)	hsa:1942
PharmGKB ID(s)	PA27656
General Description of Recombinant Human Ephrin-A1 / EFNA1 Protein.
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assbly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of bryonic neuronal growth cone and regulates dendritic spine morphogenesis.

Human Ephrin-A1 / EFNA1 Recombinant Protein Product Attributes

Product Type: Recombinant Protein

Recombinant Ephrin-A1 / EFNA1 based upon sequence from Human

Host: QP5963 protein expressed in E. coli.

Tag: His-SUMO

Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Ephrin-A1 / EFNA1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.

Application Notes: Please contact us for application specific information for QP5963.

Bioactivity Data: Untested

Full Length? Partial (see sequence information for more details).

Expression Region: Asp19 - Ser182

Amino Acid Sequence: DRHTVFWNSS NPKFRNEDYT IHVQLNDYVD IICPHYEDHS VADAAMEQYI LYLVEHEEYQ LCQPQSKDQV RWQCNRPSAK HGPEKLSEKF QRFTPFTLGK EFKEGHSYYY ISKPIHQHED RCLRLKVTVS GKITHSPQAH DNPQEKRLAA DDPEVRVLHS IGHS

Purity: Greater than 90% as determined by SDS-PAGE.

Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.

Concentration of Human Ephrin-A1 / EFNA1 Protein:

Endotoxin Levels: Not determined.

Buffer: Tris-based buffer, 50% glycerol

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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