PDF DatasheetHuman C-C motif chemokine 25 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant C-C motif chemokine 25 based upon sequence from: Human
Host: QP10240 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human C-C motif chemokine 25, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10240.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 1.0-10 ng/ml.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: MQGVFEDCCL AYHYPIGWAV LRRAWTYRIQ EVSGSCNLPA AIFYLPKRHR KVCGNPKSRE VQRAMKLLDA RNKVFAKLHH NTQTFQAGPH AVKKLSSGNS KLSSSKFSNP ISSSKRNVSL LISANSGL
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human C-C motif chemokine 25 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human C-C motif chemokine 25 Protein General Information | |
|---|---|
| Alternate Names | |
| SCYA25; TECK; Ckb15 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CCL25 |
| Entrez Gene ID | 6370 |
| Ensemble Gene ID | ENSG00000131142 |
| RefSeq Protein Accession(s) | NP_001188288.1 |
| RefSeq mRNA Accession(s) | NM_001201359.1, NM_005624.3, XM_011528177.2, XM_017027120.1, XM_017027121.1, XM_017027122.1 |
| UniProt ID(s) | O15444 |
| UniGene ID(s) | Hs.310511 |
| HGNC ID(s) | HGNC:10624 |
| COSMIC ID Link(s) | CCL25 |
| KEGG Gene ID(s) | hsa:6370 |
| PharmGKB ID(s) | PA35556 |
| General Description of Recombinant Human C-C motif chemokine 25 Protein. | |
| Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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