PDF DatasheetHuman IL-11 / interleukin 11 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL-11 / interleukin 11 based upon sequence from: Human
Host: QP5387 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5387.
Bioactivity Data: BioActivity: Shows bioactivity at a concentration of 2.5 ng/mL in the T11 cell proliferation assay. The bioactivity acceptance criteria is set at 4 x 10^5 units/mg.
Monomer or Dimer: Monomer
Amino Acid Sequence: MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human IL-11 / interleukin 11 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: Sterile filtered (0.22 um) solution containing 0.1% TFA
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human IL-11 / interleukin 11 Protein General Information | |
|---|---|
| Alternate Names | |
| IL-11, interleukin 11, AGIF, IL-11 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL11 |
| Entrez Gene ID | 3589 |
| Ensemble Gene ID | ENSG00000095752 |
| RefSeq Protein Accession(s) | NP_000632.1 |
| RefSeq mRNA Accession(s) | NM_000641.3, NM_001267718.1 |
| UniProt ID(s) | P20809 |
| UniGene ID(s) | Hs.467304 |
| HGNC ID(s) | HGNC:5966 |
| COSMIC ID Link(s) | IL11 |
| KEGG Gene ID(s) | hsa:3589 |
| PharmGKB ID(s) | PA29781 |
| General Description of Recombinant Human IL-11 / interleukin 11 Protein. | |
| Interleukin 11 (IL-11) is a member of the gp130 family of cytokines. IL-11 functions to promote hematopoietic stem cell proliferation and megakaryocyte differentiation. In non-hematopoietic cell populations, IL-11 stimulates acute-phase proteins, modulates the development of immunoglobulin-producing B cells, and regulates bone turnover. IL-11 binds the IL-11Ralpha (IL-11R?) receptor to activate JAK downstream signaling. Human IL-11 shows activity on murine cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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