PDF DatasheetMouse IL-11 / interleukin 11 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL-11 / interleukin 11 based upon sequence from: Mouse
Host: QP10459 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Mouse IL-11 / interleukin 11, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10459.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using murine T11 cells is less than 2 ng/ml, corresponding to a specific activity of > 5.0 × 105 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: MPGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM RDKFPADGDH SLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYLRHVQW LRRAGGPSLK TLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPVIP LGPPASAWGS IRAAHAILGG LHLTLDWAVR GLLLLKTRL
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Mouse IL-11 / interleukin 11 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse IL-11 / interleukin 11 Protein General Information | |
|---|---|
| Alternate Names | |
| IL-11; interleukin 11; AGIF; IL-11 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL11 |
| Entrez Gene ID | 16156 |
| Ensemble Gene ID | ENSMUSG00000004371 |
| RefSeq Protein Accession(s) | NP_032376.1 |
| RefSeq mRNA Accession(s) | NM_008350.4 |
| UniProt ID(s) | P47873 |
| UniGene ID(s) | Mm.35814 |
| COSMIC ID Link(s) | IL11 |
| KEGG Gene ID(s) | mmu:16156 |
| General Description of Recombinant Mouse IL-11 / interleukin 11 Protein. | |
| Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:8913282). Also promotes the proliferation of hepatocytes in response to liver damage (PubMed:22253262). Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers (PubMed:10026196, PubMed:23948300). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3 (PubMed:23948300, PubMed:22253262). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.