PDF DatasheetHuman IL-11 / interleukin 11 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL-11 / interleukin 11 based upon sequence from: Human
Host: QP10319 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human IL-11 / interleukin 11, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10319.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using murine B9-11 cells is less than 1 ng/ml, corresponding to a specific activity of > 1.0 × 106 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human IL-11 / interleukin 11 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human IL-11 / interleukin 11 Protein General Information | |
|---|---|
| Alternate Names | |
| IL-11; interleukin 11; AGIF; IL-11 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL11 |
| Entrez Gene ID | 3589 |
| Ensemble Gene ID | ENSG00000095752 |
| RefSeq Protein Accession(s) | NP_000632.1 |
| RefSeq mRNA Accession(s) | NM_000641.3, NM_001267718.1 |
| UniProt ID(s) | P20809 |
| UniGene ID(s) | Hs.467304 |
| HGNC ID(s) | HGNC:5966 |
| COSMIC ID Link(s) | IL11 |
| KEGG Gene ID(s) | hsa:3589 |
| PharmGKB ID(s) | PA29781 |
| General Description of Recombinant Human IL-11 / interleukin 11 Protein. | |
| Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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