PDF DatasheetHuman IL-15 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL-15 based upon sequence from Human
Host: QP1153 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP1153.
Bioactivity Data: BioActivity: Shows bioactivity at a concentration of 5 ng/mL in the CTLL-2 cell proliferation assay. The bioactivity acceptance criteria is set at 2 x 10^5 units/mg.
Monomer or Dimer: Monomer
Amino Acid Sequence: MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions: A Certificate of Analysis (CofA) will be sent along with the protein and will contain the proper reconstitution instructions.
Concentration of Human IL-15 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: 10 mM sodium bicarbonate, pH 8.0
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human IL-15 Protein General Information | |
|---|---|
| Alternate Names | |
| IL-15, IL15, Interleukin 15, IL-15 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL15 |
| Entrez Gene ID | 3600 |
| Ensemble Gene ID | ENSG00000164136 |
| RefSeq Protein Accession(s) | NP_000576.1 |
| RefSeq mRNA Accession(s) | NM_000585.4, NM_172175.2 |
| UniProt ID(s) | P40933 |
| UniGene ID(s) | Hs.168132 |
| HGNC ID(s) | HGNC:5977 |
| COSMIC ID Link(s) | IL15 |
| KEGG Gene ID(s) | hsa:3600 |
| PharmGKB ID(s) | PA29790 |
| General Description of Recombinant Human IL-15 Protein. | |
| Interleukin 15 (IL-15) is a widely expressed proinflammatory cytokine that is structurally and functionally related to interleukin 2 (IL-2). IL-15 signals through JAK kinases to activate STAT3, STAT5, and STAT6 transcription factors. IL-15 regulates the activation of T cells, neutrophils, and macrophages, and is a stimulatory cytokine promoting dendritic cell function. IL-15 expression is dysregulated in chronic inflammatory disorders, including rheumatoid arthritis, psoriasis, and pulmonary inflammatory diseases. Therefore, IL-15 may serve as an effective therapeutic target, due to the beneficial outcomes of IL-15 neutralization in models of psoriasis and diabetes. Human IL-15 shows activity on mouse cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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