PDF DatasheetHuman IL6 / Interleukin-6 Protein Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL6 / Interleukin-6 Protein based upon sequence from: Human
Host: QP10313 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human IL6 / Interleukin-6 Protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10313.
Bioactivity Data: Assay #1: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using IL-6-dependent murine 7TD1 cells is less than 0.1 ng/ml, corresponding to a specific activity of > 1.0 × 107 IU/mg. Assay #2: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using IL-6-dependent murine T1165 cells is less than 0.8 ng/ml, corresponding to a specific activity of > 1.25 ×106 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: VPPGEDSKDV AAPHRQPLTS SERIDKQIRY ILDGISALRK ETCNKSNMCE SSKEALAENN
LNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK V
LIQFLQKK AKNLDAITTP DPTTNASLLT KLQAQNQWLQ DMTTHLILRS FKEFLQSSLR AL
RQM
LNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK V
LIQFLQKK AKNLDAITTP DPTTNASLLT KLQAQNQWLQ DMTTHLILRS FKEFLQSSLR AL
RQM
Purity: Greater than 96% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human IL6 / Interleukin-6 Protein Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4. , lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human IL6 / Interleukin-6 Protein Protein General Information | |
|---|---|
| Alternate Names | |
| IL6; Interleukin-6 Protein; BSF2; IL-6; HSF; BSF-2; CDF; HGF; IFN-beta-2; IFNB2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL6 |
| Entrez Gene ID | 3569 |
| Ensemble Gene ID | ENSG00000136244 |
| RefSeq Protein Accession(s) | NP_000591.1 |
| RefSeq mRNA Accession(s) | NM_000600.4, XM_011515390.2 |
| UniProt ID(s) | P05231 |
| UniGene ID(s) | Hs.654458 |
| HGNC ID(s) | HGNC:6018 |
| COSMIC ID Link(s) | IL6 |
| KEGG Gene ID(s) | hsa:3569 |
| PharmGKB ID(s) | PA198 |
| General Description of Recombinant Human IL6 / Interleukin-6 Protein Protein. | |
| Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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