PDF DatasheetHuman M-CSF / CSF-1 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant M-CSF / CSF-1 based upon sequence from: Human
Host: QP10351 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human M-CSF / CSF-1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10351.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using murine M-NFS-60 cells is less than 1 ng/ml, corresponding to a specific activity of > 1.0 × 106 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: EEVSEYCSHM IGSGHLQSLQ RLIDSQMETS CQITFEFVDQ EQLKDPVCYL KKAFLLVQDI MEDTMRFRDN TPNAIAIVQL QELSLRLKSC FTKDYEEHDK ACVRTFYETP LQLLEKVKNV FNETKNLLDK DWNIFSKNCN NSFAECSSQG HERQSEGS
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human M-CSF / CSF-1 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0. 2um filtered PBS, pH7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human M-CSF / CSF-1 Protein General Information | |
|---|---|
| Alternate Names | |
| M-CSF; CSF-1; C87615; MCSF; Csfm | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CSF1 |
| Entrez Gene ID | 1435 |
| Ensemble Gene ID | ENSG00000184371 |
| RefSeq Protein Accession(s) | NP_000748.3 |
| RefSeq mRNA Accession(s) | NM_000757.5, NM_172210.2, NM_172211.3, NM_172212.2 |
| UniProt ID(s) | P09603 |
| UniGene ID(s) | Hs.173894 |
| HGNC ID(s) | HGNC:2432 |
| COSMIC ID Link(s) | CSF1 |
| KEGG Gene ID(s) | hsa:1435 |
| PharmGKB ID(s) | PA26935 |
| General Description of Recombinant Human M-CSF / CSF-1 Protein. | |
| Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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