PDF DatasheetHuman M-CSF / CSF-1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant M-CSF / CSF-1 based upon sequence from: Human
Host: QP9081 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) M-CSF / CSF-1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9081.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Glu33 – Val554
Amino Acid Sequence: EEVSEYCSHM IGSGHLQSLQ RLIDSQMETS CQITFEFVDQ EQLKDPVCYL KKAFLLVQDI MEDTMRFRDN TPNAIAIVQL QELSLRLKSC FTKDYEEHDK ACVRTFYETP LQLLEKVKNV FNETKNLLDK DWNIFSKNCN NSFAECSSQD VVTKPDCNCL YPKAIPSSDP ASVSPHQPLA PSMAPVAGLT WEDSEGTEGS SLLPGEQPLH TVDPGSAKQR PPRSTCQSFE PPETPVVKDS TIGGSPQPRP SVGAFNPGME DILDSAMGTN WVPEEASGEA SEIPVPQGTE LSPSRPGGGS MQTEPARPSN FLSASSPLPA SAKGQQPADV TGTALPRVGP VRPTGQDWNH TPQKTDHPSA LLRDPPEPGS PRISSLRPQG LSNPSTLSAQ PQLSRSHSSG SVLPLGELEG RRSTRDRRSP AEPEGGPASE GAARPLPRFN SVPLTDTGHE RQSEGSFSPQ LQESVFHLLV PSVILVLLAV GGLLFYRWRR RSHQEPQRAD SPLEQPEGSP LTQDDRQVEL PV
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human M-CSF / CSF-1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human M-CSF / CSF-1 Protein General Information | |
|---|---|
| Alternate Names | |
| M-CSF; CSF-1; C87615; MCSF; Csfm | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CSF1 |
| Entrez Gene ID | 1435 |
| Ensemble Gene ID | ENSG00000184371 |
| RefSeq Protein Accession(s) | NP_000748.3 |
| RefSeq mRNA Accession(s) | NM_000757.5, NM_172210.2, NM_172211.3, NM_172212.2 |
| UniProt ID(s) | P09603 |
| UniGene ID(s) | Hs.173894 |
| HGNC ID(s) | HGNC:2432 |
| COSMIC ID Link(s) | CSF1 |
| KEGG Gene ID(s) | hsa:1435 |
| PharmGKB ID(s) | PA26935 |
| General Description of Recombinant Human M-CSF / CSF-1 Protein. | |
| Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hatopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and fale fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of mbrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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