PDF DatasheetHuman Thrombopoietin / THPO Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant Thrombopoietin / THPO based upon sequence from: Human
Host: QP10387 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human Thrombopoietin / THPO, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10387.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by its ability to inhibit IGF-II induced proliferation of MCF-7 cells is less than 0.4 ug/ml, corresponding to a specific activity of > 2500 IU/mg in the presence of 15 ng/ml of rHuIGF-II.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: LGSFVHCEPC DEKALSMCPP SPLGCELVKE PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC LNEKSYREQV KIERDSREHE EPTTSEMAEE TYSPKIFRPK HTRISELKAE AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWCVDKYGMK LPGMEYVDGD FQCHTFDSSN VE
Purity: Greater than 96% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human Thrombopoietin / THPO Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.0, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Thrombopoietin / THPO Protein General Information | |
|---|---|
| Alternate Names | |
| Thrombopoietin; THPO; Ml; Mpllg; Mgdf; Tpo | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IGFBP5 |
| Entrez Gene ID | 3488 |
| Ensemble Gene ID | ENSG00000115461 |
| RefSeq Protein Accession(s) | NP_000590.1 |
| RefSeq mRNA Accession(s) | NM_000599.3 |
| UniProt ID(s) | P24593 |
| HGNC ID(s) | HGNC:5474 |
| COSMIC ID Link(s) | IGFBP5 |
| KEGG Gene ID(s) | hsa:3488 |
| PharmGKB ID(s) | PA29707 |
| General Description of Recombinant Human Thrombopoietin / THPO Protein. | |
| IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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