PDF DatasheetHuman PDGF-B Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant PDGF-B based upon sequence from: Human
Host: QP10398 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human PDGF-B, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10398.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 3 ng/ml, corresponding to a specific activity of > 3.3 × 105 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: MSLGSLTIAE PAMIAECKTR TEVFEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRPTQVQLRP VQVRKIEIVR KKPIFKKATV TLEDHLACKC ETVAAARPVT
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human PDGF-B Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human PDGF-B Protein General Information | |
|---|---|
| Alternate Names | |
| PDGF-B; IBGC5; PDGF2; SSV; PDGF-2; SIS; c-sis | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PDGFB |
| Entrez Gene ID | 5155 |
| Ensemble Gene ID | ENSG00000100311 |
| RefSeq Protein Accession(s) | NP_002599.1 |
| RefSeq mRNA Accession(s) | NM_002608.3, NM_033016.3 |
| UniProt ID(s) | P01127 |
| UniGene ID(s) | Hs.1976 |
| HGNC ID(s) | HGNC:8800 |
| COSMIC ID Link(s) | PDGFB |
| KEGG Gene ID(s) | hsa:5155 |
| PharmGKB ID(s) | PA33145 |
| General Description of Recombinant Human PDGF-B Protein. | |
| Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.