PDF DatasheetHuman CD14 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant CD14 based upon sequence from Human
Host: QP2072 protein expressed in E.coli, Mammal..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) CD14, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP2072.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Thr20 – Asn345
Amino Acid Sequence: TTPEPCELDD EDFRCVCNFS EPQPDWSEAF QCVSAVEVEI HAGGLNLEPF LKRVDADADP RQYADTVKAL RVRRLTVGAA QVPAQLLVGA LRVLAYSRLK ELTLEDLKIT GTMPPLPLEA TGLALSSLRL RNVSWATGRS WLAELQQWLK PGLKVLSIAQ AHSPAFSCEQ VRAFPALTSL DLSDNPGLGE RGLMAALCPH KFPAIQNLAL RNTGMETPTG VCAALAAAGV QPHSLDLSHN SLRATVNPSA PRCMWSSALN SLNLSFAGLE QVPKGLPAKL RVLDLSCNRL NRAPQPDELP EVDNLTLDGN PFLVPGTALP HEGSMN
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human CD14 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human CD14 Protein General Information | |
|---|---|
| Alternate Names | |
| CD14 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CD14 |
| Entrez Gene ID | 929 |
| Ensemble Gene ID | ENSG00000170458 |
| RefSeq Protein Accession(s) | NP_000582.1 |
| RefSeq mRNA Accession(s) | NM_000591.3, NM_001040021.2, NM_001174104.1, NM_001174105.1 |
| UniProt ID(s) | P08571 |
| UniGene ID(s) | Hs.163867 |
| HGNC ID(s) | HGNC:1628 |
| COSMIC ID Link(s) | CD14 |
| KEGG Gene ID(s) | hsa:929 |
| PharmGKB ID(s) | PA26188 |
| General Description of Recombinant Human CD14 Protein. | |
| In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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