PDF DatasheetSheep TNF-alpha Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant TNF-alpha based upon sequence from Sheep
Host: QP6812 protein expressed in E.coli, Yeast..
Tag: GST
Protein Construction: A DNA sequence encoding the Ovis aries (Sheep) TNF-alpha, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6812.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Leu78 – Leu234
Amino Acid Sequence: LRSSSQASNN KPVAHVVANI SAPGQLRWGD SYANALMANG VELKDNQLVV PTDGLYLIYS QVLFRGHGCP STPLFLTHTI SRIAVSYQTK VNILSAIKSP CHRETLEGAE AKPWYEPIYQ GGVFQLEKGD RLSAEINLPE YLDYAESGQV YFGIIAL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Sheep TNF-alpha Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Sheep TNF-alpha Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TNF |
| Entrez Gene ID | 443540 |
| Ensemble Gene ID | ENSOARG00000008333 |
| RefSeq Protein Accession(s) | NP_001020031.1 |
| RefSeq mRNA Accession(s) | NM_001024860.1 |
| UniProt ID(s) | P23383 |
| UniGene ID(s) | Oar.455 |
| COSMIC ID Link(s) | TNF |
| KEGG Gene ID(s) | oas:443540 |
| General Description of Recombinant Sheep TNF-alpha Protein. | |
| Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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