PDF DatasheetHuman Wilm’s Tumor 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Wilm’s Tumor 1 based upon sequence from Human
Host: QP6890 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Wilm’s Tumor 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6890.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Leu449
Amino Acid Sequence: MGSDVRDLNA LLPAVPSLGG GGGCALPVSG AAQWAPVLDF APPGASAYGS LGGPAPPPAP PPPPPPPPHS FIKQEPSWGG AEPHEEQCLS AFTVHFSGQF TGTAGACRYG PFGPPPPSQA SSGQARMFPN APYLPSCLES QPAIRNQGYS TVTFDGTPSY GHTPSHHAAQ FPNHSFKHED PMGQQGSLGE QQYSVPPPVY GCHTPTDSCT GSQALLLRTP YSSDNLYQMT SQLECMTWNQ MNLGATLKGV AAGSSSSVKW TEGQSNHSTG YESDNHTTPI LCGAQYRIHT HGVFRGIQDV RRVPGVAPTL VRSASETSEK RPFMCAYPGC NKRYFKLSHL QMHSRKHTGE KPYQCDFKDC ERRFSRSDQL KRHQRRHTGV KPFQCKTCQR KFSRSDHLKT HTRTHTGKTS EKPFSCRWPS CQKKFARSDE LVRHHNMHQR NMTKLQLAL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Wilm’s Tumor 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Wilm’s Tumor 1 Protein General Information | |
|---|---|
| Alternate Names | |
| Wilm’s Tumor 1, EWS-WT1, GUD, WIT-2, WT33, AWT1, WAGR, NPHS4 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | WT1 |
| Entrez Gene ID | 7490 |
| Ensemble Gene ID | ENSG00000184937 |
| RefSeq Protein Accession(s) | NP_000369.3 |
| RefSeq mRNA Accession(s) | NM_000378.4, NM_001198551.1, NM_001198552.1, NM_024424.3, NM_024426.4 |
| UniProt ID(s) | P19544 |
| UniGene ID(s) | Hs.591980 |
| HGNC ID(s) | HGNC:12796 |
| COSMIC ID Link(s) | WT1 |
| KEGG Gene ID(s) | hsa:7490 |
| PharmGKB ID(s) | PA37395 |
| General Description of Recombinant Human Wilm’s Tumor 1 Protein. | |
| Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5′-CGCCCCCGC-3′. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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