PDF DatasheetHuman Wilm’s Tumor 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Wilm’s Tumor 1 based upon sequence from: Human
Host: QP8720 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Wilm’s Tumor 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8720.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Gln147 – Gln446
Amino Acid Sequence: QGYSTVTFDG TPSYGHTPSH HAAQFPNHSF KHEDPMGQQG SLGEQQYSVP PPVYGCHTPT DSCTGSQALL LRTPYSSDNL YQMTSQLECM TWNQMNLGAT LKGVAAGSSS SVKWTEGQSN HSTGYESDNH TTPILCGAQY RIHTHGVFRG IQDVRRVPGV APTLVRSASE TSEKRPFMCA YPGCNKRYFK LSHLQMHSRK HTGEKPYQCD FKDCERRFSR SDQLKRHQRR HTGVKPFQCK TCQRKFSRSD HLKTHTRTHT GKTSEKPFSC RWPSCQKKFA RSDELVRHHN MHQRNMTKLQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Wilm’s Tumor 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Wilm’s Tumor 1 Protein General Information | |
|---|---|
| Alternate Names | |
| Wilm’s Tumor 1; EWS-WT1; GUD; WIT-2; WT33; AWT1; WAGR; NPHS4 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | WT1 |
| Entrez Gene ID | 7490 |
| Ensemble Gene ID | ENSG00000184937 |
| RefSeq Protein Accession(s) | NP_000369.3 |
| RefSeq mRNA Accession(s) | NM_000378.4, NM_001198551.1, NM_001198552.1, NM_024424.3, NM_024426.4 |
| UniProt ID(s) | P19544 |
| UniGene ID(s) | Hs.591980 |
| HGNC ID(s) | HGNC:12796 |
| COSMIC ID Link(s) | WT1 |
| KEGG Gene ID(s) | hsa:7490 |
| PharmGKB ID(s) | PA37395 |
| General Description of Recombinant Human Wilm’s Tumor 1 Protein. | |
| Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital syst. Recognizes and binds to the DNA sequence 5′-CGCCCCCGC-3′. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
-150x150.jpg)
-150x150.jpg)
-150x150.jpg)
-150x150.jpg)
-150x150.jpg)
There are no reviews yet.