Immunohistochemical staining of alpha-1-Antichymotrypsin  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

alpha-1-Antichymotrypsin [Polyclonal] Antibody (cGMP).

$ 135.00$ 255.00
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Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Rabbit Undetermined

Product NumberDescriptionPrice
QIVD219-0.1ml Size: 0.1 ml, Format: Concentrate $ 158.00
QIVD219-0.5ml Size: 0.5 ml, Format: Concentrate $ 178.00
QIVD219-1ml Size: 1 ml, Format: Concentrate $ 288.00
QIVD219-6ml Size: 6 ml, Format: Predilute $ 268.00
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Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:


Bioactivity (test results eg. IU/ml):

SKU: QIVD219-0.1ml
alpha-1-Antichymotrypsin General Information
Alternate Names
Molecular Weight
47.7 kDa
Chromosomal Location
q32.13 [chr: 14] [chr_start: 94612377] [chr_end: 94624055] [strand: 1]
Curated Database and Bioinformatic Data
Gene SymbolSERPINA3
Entrez Gene ID12
RefSeq Protein Accession(s)NP_001076
RefSeq mRNA Accession(s); NM_001085
RefSeq Genomic Accession(s)NG_012879; NC_000014
UniProt ID(s)P01011
PharmGKB ID(s)PA35020
KEGG Gene ID(s)hsa:12
General Description of alpha-1-Antichymotrypsin .
The antibody is specific against human alpha-1-antichymotrypsin. This antibody stains monocytes and macrophages in human tissues and does not stain any other cell type.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:25-1:50
Pretreatment No Pretreatment Required
Incubation Parameters 30 min at RoomTemperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Polyclonal
Anti-alpha-1-Antichymotrypsin Antibody Clone: Polyclonal
Host and Isotype: Rabbit Undetermined
Recommended Positive Control Sample: Tonsil
Cellular Localization of Antibody Polyclonal Staining: Cytoplasmic
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: alpha-1-antichymotrypsin isolated from human serum.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

alpha-1-Antichymotrypsin Information for Pathologists


Also called ?1-ACT. Acute phase protein / plasma protease inhibitor, mainly produced by liver in response to cytokines such as oncostatin M. May limit tissue damage produced by excessive inflammation associated proteolysis. Also localizes to nuclei of hepatic cells to control chromatin condensation and proliferation (Gastroenterology 2013;144:818). Homologous to alpha-1-antitrypsin.

Notable Clinical Features:

Heart: has role in pathophysiology of heart failure (Circ Heart Fail 2013;6:853). Kidney: part of plasma molecular profile associated with acute cellular renal allograft rejection (Transplantation 2011;92:388). Skin: has role in skin repair (J Biol Chem 2011;286:28889). Umbilical cord: may help differentiate between stillborns and liveborns (Pathol Res Pract 2009;205:534). Uses by pathologists

Common Uses By Pathologists:

Marker for acinic / acinar cell carcinoma in breast (Case Rep Oncol Med 2013;2013:372947), pancreas, salivary gland.

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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alpha-1-Antichymotrypsin [Polyclonal] Antibody (cGMP).