Formalin-fixed, paraffin-embedded human Tonsil stained with CD5 Monoclonal Antibody (C5/473 + CD5/54/F6)
Formalin-fixed, paraffin-embedded human Tonsil stained with CD5 Monoclonal Antibody (C5/473 + CD5/54/F6)

Anti-CD5 Antibody Clone C5/473 + CD5/54/F6

$ 429.00
Please Select Product Options Below To View The Catalog Number.

SKU: 921-MSM3
Species: Human, Rabbit, Cow, and Rat
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
921-MSM3-P1 Size: 100 ug, Tag: Unconjugated
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SKU: 921-MSM3-P1
CD5 General Information
Alternate Names
CD5, Cluster of Differentiation 5
Molecular Weight
67kDa
Chromosomal Location
11q12.2
Curated Database and Bioinformatic Data
Gene SymbolCD5
Entrez Gene ID921
Ensemble Gene IDENSG00000110448
RefSeq Protein Accession(s)NP_001333385, NP_055022
RefSeq mRNA Accession(s)NM_014207, NM_001346456
RefSeq Genomic Accession(s)NC_018922, NC_000011,
UniProt ID(s)P06127
UniGene ID(s)P06127
HGNC ID(s)1685
Cosmic ID(s)CD5
KEGG Gene ID(s)hsa:921
PharmGKB ID(s)PA26224
General Description of CD5.
Recognizes a 67kDa transmembrane protein, which is identified as CD5. The CD5 antigen is found on 95% of thymocytes, 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma,, a subset (~10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms. Anti-CD5 detection is diagnostic in CLL/SLL within a panel of other B-cell markers, especially one that includes anti-CD23. Anti-CD5 is also very useful in differentiating among mature small lymphoid cell malignancies. In addition, anti-CD5 can be used in distinguishing thymic carcinoma (+) from thymoma (-). Anti-CD5 does not react with granulocytes or monocytes.

Human, Rabbit, Cow, and Rat Anti-CD5 Antibody Product Attributes

Species: Human, Rabbit, Cow, and Rat
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (0.5-1ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-CD5 Antibody Clone: C5/473 + CD5/54/F6
Clone C5/473 + CD5/54/F6 Host and Isotype: Mouse IgG
Anti-Human, Rabbit, Cow, and Rat CD5 Positive Control Sample: 293T, Ramos, or MOLT-4 Cells. Tonsil.
Cellular Localization of Antibody Cell surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Human CD5 recombinant protein (C5/473); A synthetic peptide from the intracellular region of human CD5 (CD5/54/F6)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

CD5 Previously Observed Antibody Staining Patterns

Observed Antibody Staining Data By Tissue Type:

Variations in CD5 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the white pulp in spleen and non-germinal center cells in the lymph node and tonsil. More moderate antibody staining intensity was present in cells in the white pulp in spleen and non-germinal center cells in the lymph node and tonsil. Low, but measureable presence of CD5 could be seen in. We were unable to detect CD5 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Limitations and Warranty

enQuire Bio's CD5 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-CD5 Antibody Clone C5/473 + CD5/54/F6

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