Immunohistochemical staining of Transglutaminase II  of human FFPE tissue followed by incubation with HRP labeled secondary and development with DAB substrate.

Transglutaminase II [CUB 7402] Antibody (cGMP).

$ 135.00$ 775.00
Please Select Product Options Below To View The Catalog Number.

SKU: QIVD207
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Mouse IgG1

Product NumberDescriptionPrice
QIVD207-0.1ml Size: 0.1 ml, Format: Concentrate $ 135.00
QIVD207-0.5ml Size: 0.5 ml, Format: Concentrate $ 465.00
QIVD207-1ml Size: 1 ml, Format: Concentrate $ 775.00
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Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
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SKU: QIVD207-0.1ml
Transglutaminase II General Information
Alternate Names
Molecular Weight
77.3 kDa
Chromosomal Location
q11.23 [chr: 20] [chr_start: 38127385] [chr_end: 38166578] [strand: -1]
Curated Database and Bioinformatic Data
Gene SymbolTGM2
Entrez Gene ID7052
RefSeq Protein Accession(s)NP_004604; NP_001310245; NP_945189; XP_011527330
RefSeq mRNA Accession(s)NM_198951; NM_001323316; NM_001323317; NM_004613; XM_011529028; NM_001323318
RefSeq Genomic Accession(s)NC_000020
UniProt ID(s)P21980
PharmGKB ID(s)PA36491
KEGG Gene ID(s)hsa:7052
General Description of Transglutaminase II .
This antibody reacts with a 77-85 kDa protein known as transglutaminase II (TGase II). TGase II catalyzes calcium-dependent post-translational modification of proteins by formation of an isopeptide bond within or between polypeptide chains. Different tissue and cell types express varying amounts of tissue transglutaminase.

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
Specification Recommendation
Recommended Dilution (Conc) 1:50-1:75
Pretreatment Citrate Buffer pH 6.0
Incubation Parameters 30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal
Anti-Transglutaminase II Antibody Clone: CUB 7402
Host and Isotype: Mouse IgG1
Recommended Positive Control Sample: Breast carcinoma
Cellular Localization of Antibody CUB 7402 Staining: Cytoplasmic, cell membrane, extracellular matrix
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: BALB/C mice were injected with purified guinea pig liver transglutaminase.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

Transglutaminase II Information for Pathologists

Summary:

Transglutaminase II has been implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.

Common Uses By Pathologists:

Different tissues and cell types express varying amounts of tissue transglutaminase with a markedly hugh expression in rheumatoid lesions.

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

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Transglutaminase II [CUB 7402] Antibody (cGMP).