SDS –PAGE Analysis  Purified p53 Recombinant Rabbit Monoclonal Antibody (TP53/1799R).Confirmation of Purity and Integrity.
SDS –PAGE Analysis  Purified p53 Recombinant Rabbit Monoclonal Antibody (TP53/1799R).Confirmation of Purity and Integrity.Analysis of Protein Array containing more than 19,000 full-length human proteins using p53 Recombinant Rabbit Monoclonal Antibody (TP53/1799R)Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.Western blot analysis of Hela cell lysate using p53 Recombinant Rabbit Monoclonal Antibody (TP53/1799R).Western blot analysis of Hela cell lysate using p53 Recombinant Rabbit Monoclonal Antibody (TP53/1799R).

Anti-p53 Tumor Suppressor Protein Antibody Clone TP53/1799R

$ 199.00$ 429.00
Please Select Product Options Below To View The Catalog Number.

SKU: 7157-RBM10
Species: Human
Tested Applications: WB, IHC
Available Conjugates: Unconjugated
Isotype: Rabbit IgG
Mass Spec Validated?: Not MS Validated

Product NumberDescriptionPrice
7157-RBM10-P0 Size: 20 ug, Tag: Unconjugated $ 199.00
7157-RBM10-P1 Size: 100 ug, Tag: Unconjugated $ 429.00
7157-RBM10-P1ABX Size: 100 ug, Tag: Unconjugated $ 429.00
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SKU: 7157-RBM10-P0
p53 Tumor Suppressor Protein General Information
Alternate Names
Antigen NY-CO-13, BCC7, Cellular Tumor Antigen p53, LFS1, TP53, Transformation Related Protein 53 (TRP53), Tumor Protein p53, Tumor Suppressor p53
Molecular Weight
Chromosomal Location
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Curated Database and Bioinformatic Data
Gene Symbol7157
Entrez Gene IDTP53
UniProt ID(s)P04637
UniGene ID(s)Hs654481
KEGG Gene ID(s)hsa:7157
General Description of p53 Tumor Suppressor Protein.
The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 protein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

Human Anti-p53 Tumor Suppressor Protein Antibody Product Attributes

Species: Human
Tested Applications: WB, IHC.
Clonality: Monoclonal
Anti-p53 Tumor Suppressor Protein Antibody Clone: TP53/1799R
Clone TP53/1799R Host and Isotype: Rabbit IgG
Anti-Human p53 Tumor Suppressor Protein Positive Control Sample: MDA-MB-231 Cells. Breast or Colon carcinoma
Cellular Localization of Antibody TP53/1799R Staining: Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant full-length human TP53 protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.

p53 Tumor Suppressor Protein Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Variations in p53 Tumor Suppressor Protein antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of p53 Tumor Suppressor Protein could be seen inglandular cells in the adrenal gland, hematopoietic cells in the bone marrow, glandular cells in the breast, respiratory epithelial cells in the bronchus, neuronal cells in the caudate nucleus, glandular cells in the cervix, uterine and endometrium, cells in the glomeruli in kidney, islets of Langerhans in pancreas, glandular cells in the parathyroid gland, decidual cells in the placenta, glandular cells in the salivary gland, fibroblasts in skin, cells in the white pulp in spleen, non-germinal center cells in the tonsil and squamous epithelial cells in the vagina. We were unable to detect p53 Tumor Suppressor Protein in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Type:

Tissues from cancer patients, for instance, have their own distinct pattern of p53 Tumor Suppressor Protein expression as measured by anti-p53 Tumor Suppressor Protein antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity - - + + - - - - + - + - ++ - - + + + - ++
TP53 Variability + + ++ ++ + ++ ++ ++ ++ ++ +++ ++ ++ + + ++ ++ ++ + +++

Limitations and Warranty

enQuire Bio's product, p53 Tumor Suppressor Protein MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.

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Anti-p53 Tumor Suppressor Protein Antibody Clone TP53/1799R