PDF DatasheetHuman P4HB / ERBA2L Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant P4HB / ERBA2L based upon sequence from Human
Host: QP6460 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) P4HB / ERBA2L, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6460.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Asp18 – Leu508
Amino Acid Sequence: DAPEEEDHVL VLRKSNFAEA LAAHKYLLVE FYAPWCGHCK ALAPEYAKAA GKLKAEGSEI RLAKVDATEE SDLAQQYGVR GYPTIKFFRN GDTASPKEYT AGREADDIVN WLKKRTGPAA TTLPDGAAAE SLVESSEVAV IGFFKDVESD SAKQFLQAAE AIDDIPFGIT SNSDVFSKYQ LDKDGVVLFK KFDEGRNNFE GEVTKENLLD FIKHNQLPLV IEFTEQTAPK IFGGEIKTHI LLFLPKSVSD YDGKLSNFKT AAESFKGKIL FIFIDSDHTD NQRILEFFGL KKEECPAVRL ITLEEEMTKY KPESEELTAE RITEFCHRFL EGKIKPHLMS QELPEDWDKQ PVKVLVGKNF EDVAFDEKKN VFVEFYAPWC GHCKQLAPIW DKLGETYKDH ENIVIAKMDS TANEVEAVKV HSFPTLKFFP ASADRTVIDY NGERTLDGFK KFLESGGQDG AGDDDDLEDL EEAEEPDMEE DDDQKAVKDE L
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human P4HB / ERBA2L Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human P4HB / ERBA2L Protein General Information | |
|---|---|
| Alternate Names | |
| P4HB, ERBA2L, PHDB, P4Hbeta, PO4DB, PROHB, ERBA2L, GIT, DSI, PDI, CLCRP1, PDIA1, PO4HB | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | P4hb |
| Entrez Gene ID | 5034 |
| Ensemble Gene ID | ENSG00000185624 |
| RefSeq Protein Accession(s) | NP_000909.2 |
| RefSeq mRNA Accession(s) | NM_000918.3 |
| UniProt ID(s) | P07237 |
| UniGene ID(s) | Hs.464336 |
| HGNC ID(s) | HGNC:8548 |
| COSMIC ID Link(s) | P4hb |
| KEGG Gene ID(s) | hsa:5034 |
| PharmGKB ID(s) | PA32876 |
| General Description of Recombinant Human P4HB / ERBA2L Protein. | |
| This multifunctional protein catalyzes the formation, breakage and rearrangent of disulfide bonds. At the cell surface, ses to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, ses to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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