PDF DatasheetHuman P4HB / ERBA2L Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant P4HB / ERBA2L based upon sequence from: Human
Host: QP8314 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) P4HB / ERBA2L, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8314.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Leu29 – Pro313
Amino Acid Sequence: LRKSNFAEAL AAHKYLLVEF YAPWCGHCKA LAPEYAKAAG KLKAEGSEIR LAKVDATEES DLAQQYGVRG YPTIKFFRNG DTASPKEYTA GREADDIVNW LKKRTGPAAT TLPDGAAAES LVESSEVAVI GFFKDVESDS AKQFLQAAEA IDDIPFGITS NSDVFSKYQL DKDGVVLFKK FDEGRNNFEG EVTKENLLDF IKHNQLPLVI EFTEQTAPKI FGGEIKTHIL LFLPKSVSDY DGKLSNFKTA AESFKGKILF IFIDSDHTDN QRILEFFGLK KEECP
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human P4HB / ERBA2L Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human P4HB / ERBA2L Protein General Information | |
|---|---|
| Alternate Names | |
| P4HB; ERBA2L; PHDB; P4Hbeta; PO4DB; PROHB; ERBA2L; GIT; DSI; PDI; CLCRP1; PDIA1; PO4HB | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | P4hb |
| Entrez Gene ID | 5034 |
| Ensemble Gene ID | ENSG00000185624 |
| RefSeq Protein Accession(s) | NP_000909.2 |
| RefSeq mRNA Accession(s) | NM_000918.3 |
| UniProt ID(s) | P07237 |
| UniGene ID(s) | Hs.464336 |
| HGNC ID(s) | HGNC:8548 |
| COSMIC ID Link(s) | P4hb |
| KEGG Gene ID(s) | hsa:5034 |
| PharmGKB ID(s) | PA32876 |
| General Description of Recombinant Human P4HB / ERBA2L Protein. | |
| This multifunctional protein catalyzes the formation, breakage and rearrangent of disulfide bonds. At the cell surface, ses to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, ses to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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