PDF DatasheetBovine TGF-beta 1 / TGFB1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant TGF-beta 1 / TGFB1 based upon sequence from Bovine
Host: QP6778 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Bos taurus (Bovine) TGF-beta 1 / TGFB1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6778.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ala279 – Ser390
Amino Acid Sequence: ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Bovine TGF-beta 1 / TGFB1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Bovine TGF-beta 1 / TGFB1 Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TGFB1 |
| Entrez Gene ID | 282089 |
| RefSeq Protein Accession(s) | NP_001159540.1 |
| RefSeq mRNA Accession(s) | NM_001166068.1 |
| UniProt ID(s) | P18341 |
| UniGene ID(s) | Bt.469 |
| COSMIC ID Link(s) | TGFB1 |
| KEGG Gene ID(s) | bta:282089 |
| General Description of Recombinant Bovine TGF-beta 1 / TGFB1 Protein. | |
| Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone rodeling as it is a potent stimulator of osteoblastic bone formation, causing chotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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