PDF DatasheetRat TGF-beta 1 / TGFB1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant TGF-beta 1 / TGFB1 based upon sequence from Rat
Host: QP6780 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Rattus norvegicus (Rat) TGF-beta 1 / TGFB1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6780.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Leu30 – Arg278
Amino Acid Sequence: LSTCKTIDME LVKRKRIEAI RGQILSKLRL ASPPSQGEVP PGPLPEAVLA LYNSTRDRVA GESADPEPEP EADYYAKEVT RVLMVDRNNA IYDKTKDITH SIYMFFNTSD IREAVPEPPL LSRAELRLQR FKSTVEQHVE LYQKYSNNSW RYLGNRLLTP TDTPEWLSFD VTGVVRQWLN QGDGIQGFRF SAHCSCDSKD NVLHVEINGI SPKRRGDLGT IHDMNRPFLL LMATPLERAQ HLHSSRHRR
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Rat TGF-beta 1 / TGFB1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Rat TGF-beta 1 / TGFB1 Protein General Information | |
|---|---|
| Alternate Names | |
| TGF-beta 1, TGFB1, CED, TGFB, TGFbeta, LAP, DPD1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TGFB1 |
| Entrez Gene ID | 59086 |
| Ensemble Gene ID | ENSRNOG00000020652 |
| RefSeq Protein Accession(s) | NP_067589.1 |
| RefSeq mRNA Accession(s) | NM_021578.2 |
| UniProt ID(s) | P17246 |
| UniGene ID(s) | Rn.40136 |
| COSMIC ID Link(s) | TGFB1 |
| KEGG Gene ID(s) | rno:59086 |
| General Description of Recombinant Rat TGF-beta 1 / TGFB1 Protein. | |
| Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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