PDF DatasheetHuman TGF-beta 1 / TGFB1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant TGF-beta 1 / TGFB1 based upon sequence from: Human
Host: QP8568 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) TGF-beta 1 / TGFB1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8568.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Asp279 – Ser390
Amino Acid Sequence: DTNYCFSSTE KNCCVRQLYI DFRKDLGWKW IHEPKGYHAN FCLGPCPYIW SLDTQYSKVL ALYNQHNPGA SAAPCCVPQA LEPLPIVYYV GRKPKVEQLS NMIVRSCKCS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human TGF-beta 1 / TGFB1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human TGF-beta 1 / TGFB1 Protein General Information | |
|---|---|
| Alternate Names | |
| TGF-beta 1; TGFB1; TGF-beta1; Tgfb; Tgfb-1; TGFbeta1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TGFB1 |
| Entrez Gene ID | 7040 |
| Ensemble Gene ID | ENSG00000105329 |
| RefSeq Protein Accession(s) | NP_000651.3 |
| RefSeq mRNA Accession(s) | NM_000660.6 |
| UniProt ID(s) | P01137 |
| UniGene ID(s) | Hs.645227 |
| HGNC ID(s) | HGNC:11766 |
| COSMIC ID Link(s) | TGFB1 |
| KEGG Gene ID(s) | hsa:7040 |
| PharmGKB ID(s) | PA350 |
| General Description of Recombinant Human TGF-beta 1 / TGFB1 Protein. | |
| Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone rodeling as it is a potent stimulator of osteoblastic bone formation, causing chotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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