PDF DatasheetHuman CD40L / CD154 / TNFSF5 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant CD40L / CD154 / TNFSF5 based upon sequence from: Human
Host: QP5332 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5332.
Bioactivity Data: Human CD40L / CD154 / TNFSF5 induces IL-8 production by human PBMCs (which is detected via ELISA).
Monomer or Dimer: Monomer
Amino Acid Sequence: MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENGKQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LWLKSPGRFE RILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSHGTG FTSFGLLKL
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human CD40L / CD154 / TNFSF5 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: 10 mM sodium phosphate, pH 7.5
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human CD40L / CD154 / TNFSF5 Protein General Information | |
|---|---|
| Alternate Names | |
| CD40L, CD154, TNFSF5, CD154, IGM, Ly-62, TRAP, Tnlg8b, HIGM1, CD40-L, Cd40l, Ly62, T-BAM, IMD3, Tnfsf5, gp39 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CD40LG |
| Entrez Gene ID | 959 |
| Ensemble Gene ID | ENSG00000102245 |
| RefSeq Protein Accession(s) | NP_000065.1 |
| RefSeq mRNA Accession(s) | NM_000074.2 |
| UniProt ID(s) | P29965 |
| UniGene ID(s) | Hs.592244 |
| HGNC ID(s) | HGNC:11935 |
| COSMIC ID Link(s) | CD40LG |
| KEGG Gene ID(s) | hsa:959 |
| PharmGKB ID(s) | PA36626 |
| General Description of Recombinant Human CD40L / CD154 / TNFSF5 Protein . | |
| CD40 Ligand (CD40L), or CD154, is a membrane glycoprotein and differentiation antigen that is expressed on the surface of T cells, monocytes, basophils, eosinophils, platelets, dendritic cells, and endothelial cells. CD40L binds and activates the CD40 receptor on antigen-presenting cells. CD40L stimulates B cell proliferation, immunoglobulin class switching, and antibody secretion. CD40L also induces cytokine production and tumoricidal activity in peripheral blood monocytes. CD40L is a co-stimulator of activated T cell proliferation and inflammatory protein production. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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