PDF DatasheetHuman CD40L / CD154 / TNFSF5 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant CD40L / CD154 / TNFSF5 based upon sequence from: Human
Host: QP10359 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human CD40L / CD154 / TNFSF5, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10359.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by the dose-dependent stimulation of IL-8 production by human PBMC is less than 5-10 ng/ml.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENGKQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LWLKSPGRFE RILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSHGTG FTSFGLLKL
Purity: Greater than 95% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human CD40L / CD154 / TNFSF5 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.0, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human CD40L / CD154 / TNFSF5 Protein General Information | |
|---|---|
| Alternate Names | |
| CD40L; CD154; TNFSF5; CD154; IGM; Ly-62; TRAP; Tnlg8b; HIGM1; CD40-L; Cd40l; Ly62; T-BAM; IMD3; Tnfsf5; gp39 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CD40LG |
| Entrez Gene ID | 959 |
| Ensemble Gene ID | ENSG00000102245 |
| RefSeq Protein Accession(s) | NP_000065.1 |
| RefSeq mRNA Accession(s) | NM_000074.2 |
| UniProt ID(s) | P29965 |
| UniGene ID(s) | Hs.592244 |
| HGNC ID(s) | HGNC:11935 |
| COSMIC ID Link(s) | CD40LG |
| KEGG Gene ID(s) | hsa:959 |
| PharmGKB ID(s) | PA36626 |
| General Description of Recombinant Human CD40L / CD154 / TNFSF5 Protein. | |
| Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. ; Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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