PDF DatasheetHuman CD40L / CD154 / TNFSF5 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant CD40L / CD154 / TNFSF5 based upon sequence from: Human
Host: QP9047 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) CD40L / CD154 / TNFSF5, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9047.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: His47 – Leu261
Amino Acid Sequence: HRRLDKIEDE RNLHEDFVFM KTIQRCNTGE RSLSLLNCEE IKSQFEGFVK DIMLNKEETK KENSFEMQKG DQNPQIAAHV ISEASSKTTS VLQWAEKGYY TMSNNLVTLE NGKQLTVKRQ GLYYIYAQVT FCSNREASSQ APFIASLCLK SPGRFERILL RAANTHSSAK PCGQQSIHLG GVFELQPGAS VFVNVTDPSQ VSHGTGFTSF GLLKL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human CD40L / CD154 / TNFSF5 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human CD40L / CD154 / TNFSF5 Protein General Information | |
|---|---|
| Alternate Names | |
| CD40L; CD154; TNFSF5; CD154; IGM; Ly-62; TRAP; Tnlg8b; HIGM1; CD40-L; Cd40l; Ly62; T-BAM; IMD3; Tnfsf5; gp39 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CD40LG |
| Entrez Gene ID | 959 |
| Ensemble Gene ID | ENSG00000102245 |
| RefSeq Protein Accession(s) | NP_000065.1 |
| RefSeq mRNA Accession(s) | NM_000074.2 |
| UniProt ID(s) | P29965 |
| UniGene ID(s) | Hs.592244 |
| HGNC ID(s) | HGNC:11935 |
| COSMIC ID Link(s) | CD40LG |
| KEGG Gene ID(s) | hsa:959 |
| PharmGKB ID(s) | PA36626 |
| General Description of Recombinant Human CD40L / CD154 / TNFSF5 Protein. | |
| Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway. |
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Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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