PDF DatasheetHuman IL4 / Interleukin-4 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL4 / Interleukin-4 based upon sequence from: Human
Host: QP5233 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5233.
Bioactivity Data: BioActivity: Shows bioactivity at a concentration of 250 pg/mL in the TF-1 cell proliferation assay. The bioactivity acceptance criteria is set at 4 x 10^6 units/mg.
Monomer or Dimer: Monomer
Amino Acid Sequence: MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human IL4 / Interleukin-4 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: Sterile filtered (0.22 um) solution containing 0.1% TFA
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human IL4 / Interleukin-4 Protein General Information | |
|---|---|
| Alternate Names | |
| IL4, Interleukin-4, BSF-1, BSF1, IL-4, BCGF1, BCGF-1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL4 |
| Entrez Gene ID | 3565 |
| Ensemble Gene ID | ENSG00000113520 |
| RefSeq Protein Accession(s) | NP_000580.1 |
| RefSeq mRNA Accession(s) | NM_000589.3, NM_172348.2 |
| UniProt ID(s) | P05112 |
| UniGene ID(s) | Hs.73917 |
| HGNC ID(s) | HGNC:6014 |
| COSMIC ID Link(s) | IL4 |
| KEGG Gene ID(s) | hsa:3565 |
| PharmGKB ID(s) | PA197 |
| General Description of Recombinant Human IL4 / Interleukin-4 Protein. | |
| Interleukin 4 (IL-4) is an immunomodulatory cytokine that functions to induce naïve helper T cells to differentiate into type 2 T helper (Th2) cells. Th2 cells subsequently produce more IL-4 in a positive feedback loop. IL-4 also promotes immunoglobulin IgG to IgE isotype switching on B cells. IL-4 binds the IL-4R? receptor to activate STAT6 signaling. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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