PDF DatasheetHuman IL4 / Interleukin-4 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL4 / Interleukin-4 based upon sequence from: Human
Host: QP10311 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human IL4 / Interleukin-4, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10311.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.2 ng/ml, corresponding to a specific activity of > 5.0 × 106 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: HKCDITLQEI IKTLNSLTEQ KTLCTELTVT DIFAASKNTT EKETFCRAAT VLRQFYSHHE KDTRCLGATA QQFHRHKQLI RFLKRLDRNL WGLAGLNSCP VKEANQSTLE NFLERLKTIM REKYSKCSS
Purity: Greater than 98% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human IL4 / Interleukin-4 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human IL4 / Interleukin-4 Protein General Information | |
|---|---|
| Alternate Names | |
| IL4; Interleukin-4; BSF-1; BSF1; IL-4; BCGF1; BCGF-1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL4 |
| Entrez Gene ID | 3565 |
| Ensemble Gene ID | ENSG00000113520 |
| RefSeq Protein Accession(s) | NP_000580.1 |
| RefSeq mRNA Accession(s) | NM_000589.3, NM_172348.2 |
| UniProt ID(s) | P05112 |
| UniGene ID(s) | Hs.73917 |
| HGNC ID(s) | HGNC:6014 |
| COSMIC ID Link(s) | IL4 |
| KEGG Gene ID(s) | hsa:3565 |
| PharmGKB ID(s) | PA197 |
| General Description of Recombinant Human IL4 / Interleukin-4 Protein. | |
| Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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